Goehring Lutz S, van Winden Steven C, van Maanen C, Sloet van Oldruitenborgh-Oosterbaan Marianne M
Department of Equine Sciences, Division of Internal Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
J Vet Intern Med. 2006 May-Jun;20(3):601-7. doi: 10.1892/0891-6640(2006)20[601:ehtami]2.0.co;2.
Equine herpesvirus type 1(EHV-1)-associated myeloencephalopathy (EHM) is a rare disease affecting the central nervous system and, in particular, the spinal cord of horses. Epidemiologic data are limited, and usually are restricted to the description of a single outbreak. During an observational period of 4 years, we evaluated 9 outbreaks of EHM in The Netherlands. A risk factor analysis was done on the data from 6 outbreaks. Findings were: regular appearance of EHM outbreaks in The Netherlands (2-3/y); strong association of EHM with season; and risk factors, such as breed, sex, age, and fever. Female horses, aged horses, and specific breeds were at greater risk to develop severe neurologic disease. Other breeds and horses <3 years old were never observed to suffer from EHM during these outbreaks. It was concluded that breed variation, in addition to the presence of a specific EHV-1 strain, and environmental factors influence an outbreak of EHM on a premise.
1型马疱疹病毒（EHV-1）相关的脊髓炎（EHM）是一种影响中枢神经系统，尤其是马脊髓的罕见疾病。流行病学数据有限，通常仅限于对单次疫情的描述。在4年的观察期内，我们评估了荷兰的9起EHM疫情。对其中6起疫情的数据进行了风险因素分析。结果发现：EHM疫情在荷兰定期出现（每年2-3次）；EHM与季节密切相关；以及品种、性别、年龄和发热等风险因素。母马、老龄马和特定品种的马患严重神经系统疾病的风险更高。在这些疫情期间，从未观察到其他品种的马和3岁以下的马患有EHM。得出的结论是，除了特定EHV-1毒株的存在外，品种差异和环境因素在一定前提下影响EHM的爆发。
