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克罗恩病狭窄成形术后的无干预间隔期。

Intervention-free interval following strictureplasty for Crohn's Disease.

作者信息

Roy Pratik, Kumar Devinder

机构信息

Department of Colorectal Surgery, St. George's Hospital, Blackshaw Road, London SW17 0QT, UK.

出版信息

World J Surg. 2006 Jun;30(6):1020-6. doi: 10.1007/s00268-005-0284-6.

Abstract

INTRODUCTION

Strictureplasty is now well established as a bowel-sparing alternative for surgical treatment of complicated Crohn's disease. Limited resection is still preferred in patients with uncomplicated disease, as subsequent reoperation rates are low.

METHODS

A retrospective review of 26 patients who underwent surgery for small bowel Crohn's disease between 1996 and 2004 was undertaken. A total of 96 small bowel strictureplasties had been performed; 19 patients had strictureplasties performed in isolation, and the remaining 7 patients underwent strictureplasty with concomitant limited resection.

RESULTS

There was no operative mortality. The median follow-up was 41 months. Four patients developed complications that required further surgery. At 41 months, 73.3% of patients undergoing strictureplasty alone and 79.7% undergoing strictureplasty with concomitant resection were intervention-free. If followed up to 70 months or more, the same proportion of patients would remain intervention-free. Four patients developed further recrudescent disease and required surgery: strictureplasty, limited resection, or both. Of these patients, 25% were intervention-free at 41 months.

CONCLUSIONS

Our results show that strictureplasty alone or with concomitant resection can confer intervention-free periods of 41 months or more in 73.3% of patients, suggesting that strictureplasty can be utilized as an alternative to limited resection in uncomplicated Crohn's disease.

摘要

引言

狭窄成形术现已成为治疗复杂性克罗恩病的一种成熟的保留肠段的手术替代方法。对于病情不复杂的患者,仍首选有限切除,因为后续再次手术率较低。

方法

对1996年至2004年间因小肠克罗恩病接受手术的26例患者进行回顾性研究。共进行了96例小肠狭窄成形术;19例患者单独进行了狭窄成形术,其余7例患者在进行狭窄成形术的同时进行了有限切除。

结果

无手术死亡病例。中位随访时间为41个月。4例患者出现并发症,需要进一步手术。在41个月时,单独接受狭窄成形术的患者中有73.3%以及接受狭窄成形术并同时进行切除的患者中有79.7%未接受干预。如果随访至70个月或更长时间,相同比例的患者仍将未接受干预。4例患者疾病复发,需要手术:狭窄成形术、有限切除或两者都做。在这些患者中,41个月时25%未接受干预。

结论

我们的结果表明,单独或同时进行切除的狭窄成形术可使73.3%的患者无干预期达到41个月或更长,这表明狭窄成形术可作为病情不复杂的克罗恩病有限切除的替代方法。

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