Adrogué H J
Baylor College of Medicine and The Methodist Hospital, Houston, USA.
J Nephrol. 2006 Mar-Apr;19 Suppl 9:S62-9.
Derangements in the intermediate metabolism of nutrients can lead to organic acid acidoses, which in turn can have severe clinical consequences that include even the patient's death. Lactic acidosis and ketoacidosis represent the most relevant clinical forms of this type of metabolic acidosis. Assessment and proper management of the organic acid acidoses require the intervention of a skillful clinician that balances the potential benefits and risks of the prescribed measures to the specific needs of the individual patient. To this aim, knowledge of the pathophysiology, diagnosis, and therapy of the various forms of acidoses including alkali administration, represent essential requirements.
营养物质中间代谢紊乱可导致有机酸酸中毒，进而可能产生严重的临床后果，甚至包括患者死亡。乳酸酸中毒和酮症酸中毒是这类代谢性酸中毒最相关的临床形式。评估和妥善处理有机酸酸中毒需要经验丰富的临床医生进行干预，根据个体患者的具体需求权衡所采取措施的潜在益处和风险。为此，了解各种酸中毒形式的病理生理学、诊断和治疗方法，包括碱的使用，是必不可少的要求。
