Acker Till, Fandrey Joachim, Acker Helmut
Neurologisches Institut, Edinger Institut, Klinikum der J.W. Goethe Universität Frankfurt am Main, Deutschordenstr. 46, D-60528 Frankfurt, Germany.
Cardiovasc Res. 2006 Jul 15;71(2):195-207. doi: 10.1016/j.cardiores.2006.04.008. Epub 2006 Apr 22.
Current concepts of cellular oxygen-sensing include an isoform of the neutrophil NADPH oxidase, different electron carrier units of the mitochondrial electron transport chain (ETC), heme oxygenase-2 (HO-2), and a subfamily of 2-oxoglutarate dependent dioxygenases termed HIF (hypoxia inducible factor) prolyl hydroxylases (PHDs) and HIF asparagyl hydroxylase FIH-1 (factor-inhibiting HIF). Different oxygen sensitivities, cell-specific distribution and subcellular localization of specific oxygen-sensing cascades involving reactive oxygen species (ROS) as second messengers may help to tailor various adaptive responses according to differences in tissue oxygen availability. Herein, we propose an integrated model for these various oxygen-sensing mechanisms that very efficiently regulate HIF-alpha activity and plasma membrane potassium-channel (PMPC) conductivity.
目前细胞氧感应的概念包括中性粒细胞NADPH氧化酶的一种同工型、线粒体电子传递链（ETC）的不同电子载体单元、血红素加氧酶-2（HO-2），以及一个依赖2-氧代戊二酸的双加氧酶亚家族，称为缺氧诱导因子（HIF）脯氨酰羟化酶（PHD）和HIF天冬酰胺羟化酶FIH-1（抑制HIF的因子）。涉及活性氧（ROS）作为第二信使的特定氧感应级联反应具有不同的氧敏感性、细胞特异性分布和亚细胞定位，这可能有助于根据组织氧可用性的差异调整各种适应性反应。在此，我们提出了一个针对这些各种氧感应机制的整合模型，该模型能非常有效地调节HIF-α活性和质膜钾通道（PMPC）传导性。
