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大鼠的泌乳发生。分娩时代谢参数的变化。

Lactogenesis in the rat. Changes in metabolic parameters at parturition.

机构信息

Graduate Department of Biochemistry, Brandeis University, Waltham, Mass. 02154, U.S.A.

出版信息

Biochem J. 1967 Dec;105(3):995-1002. doi: 10.1042/bj1050995.

DOI:10.1042/bj1050995
PMID:16742576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1198418/
Abstract
  1. Tissue concentrations of nucleic acids, protein, fat, water, metabolites and lactose, and the activities of seven enzymes concerned in milk biosynthesis, were measured in the rat mammary gland at closely spaced times before, at and after parturition. 2. Changes are seen in the tissue concentrations of most substances, and several changes are initiated at least during the day preceding parturition. 3. Lactose, which is absent 1 day before parturition, is found in amounts of 12mumoles/g. fresh wt. of tissue at parturition. 4. From the tissue activities before parturition of three enzymes on the biosynthetic pathway of lactose, and, from the small changes observed in their activities at parturition itself, it is concluded that the factors responsible for the appearance of lactose at parturition remain to be demonstrated.
摘要
  1. 在大鼠乳腺分娩前、分娩时和分娩后接近的时间间隔内,测量了组织中核酸、蛋白质、脂肪、水、代谢物和乳糖的浓度,以及与乳合成有关的七种酶的活性。

  2. 大多数物质的组织浓度发生变化,至少有几种变化是在分娩前一天开始的。

  3. 在分娩前一天乳糖含量为零,而在分娩时组织中乳糖的含量达到 12 毫摩尔/克湿重。

  4. 从乳糖生物合成途径中三种酶在分娩前的组织活性,以及从分娩时这些酶活性的微小变化来看,可以得出结论,分娩时乳糖出现的原因仍有待证明。

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本文引用的文献

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Changes in the arginase and alkaline phosphatase contents of the mammary gland and liver of the rat during pregnancy, lactation and mammary involution.大鼠在怀孕、哺乳和乳腺退化期间乳腺和肝脏中精氨酸酶及碱性磷酸酶含量的变化。
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ENZYMES OF GALACTOSE SYNTHESIS IN MAMMARY GLAND AND MAMMARY TUMORS OF THE RAT.大鼠乳腺及乳腺肿瘤中半乳糖合成酶
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CHANGES IN THE LIPOLYTIC ACTIVITY OF THE GUINEA PIG MAMMARY GLAND AT PARTURITION.豚鼠乳腺在分娩时脂解活性的变化。
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THE LIPOPROTEIN LIPASE OF MAMMARY GLAND AND THE CORRELATION OF ITS ACTIVITY TO LACTATION.乳腺脂蛋白脂肪酶及其活性与泌乳的相关性
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THE UPTAKE FROM THE BLOOD OF TRIGLYCERIDE FATTY ACIDS OF CHYLOMICRA AND LOW-DENSITY LIPOPROTEINS BY THE MAMMARY GLAND OF THE GOAT.山羊乳腺对乳糜微粒和低密度脂蛋白中甘油三酯脂肪酸的血液摄取情况
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