Drucker-Colín R R, Spanis C W, Cotman C W, McGaugh J L
Science. 1975 Mar 14;187(4180):963-5. doi: 10.1126/science.167436.
Perfusates from the brains of freely moving cats, obtained by means of a push-pull cannula, contain high concentrations of proteins. The levels vary in a cyclic fashion and are higher during rapid eye movement sleep than during the waking state. The proteins represent a distinctive class of tissue protein and their changing levels appear to reflect an alteration in the protein content of the extracellular space of brain related to behavioral state.
通过推挽式套管从自由活动的猫脑中获取的灌流液含有高浓度的蛋白质。其水平呈周期性变化，在快速眼动睡眠期间比清醒状态时更高。这些蛋白质代表了一类独特的组织蛋白，其水平的变化似乎反映了与行为状态相关的脑细胞外空间蛋白质含量的改变。
