Weber G F, Maertens P, Meng X Z, Pippenger C E
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Lancet. 1991 Jun 15;337(8755):1443-4. doi: 10.1016/0140-6736(91)93130-2.
4 children with intractable seizures, repeated infections, and intolerance to anticonvulsants had evidence of glutathione peroxidase deficiency. 2 had low intracellular enzyme activity but normal blood selenium and high plasma glutathione peroxidase concentrations. The other 2 had low intracellular glutathione peroxidase activity with low circulating glutathione peroxidase and selenium concentrations. The clinical state of the children improved after discontinuation of anticonvulsant medication and selenium substitution.
4名患有顽固性癫痫、反复感染且对抗惊厥药不耐受的儿童有谷胱甘肽过氧化物酶缺乏的证据。2名儿童细胞内酶活性低，但血硒正常，血浆谷胱甘肽过氧化物酶浓度高。另外2名儿童细胞内谷胱甘肽过氧化物酶活性低，循环中的谷胱甘肽过氧化物酶和硒浓度也低。停用抗惊厥药物并进行硒替代后，这些儿童的临床状态有所改善。
