El-Sharif Nuha, Douwes Jeroen, Hoet Peter, Nemery Benoit
Laboratorium voor Longtoxicologie, Leuven, KU, Belgium.
J Asthma. 2006 Apr;43(3):241-7. doi: 10.1080/02770900600567122.
This study was carried out to evaluate the relationship between wheezing or sensitization and concentrations of mites, cat and dog allergens, and bacterial endotoxin in Palestine. A nested case-control involved analysis of mattress and floor dust from a 110 children's houses with reported wheezing and without wheezing. We found no consistent associations between allergen levels and either wheeze or specific atopic sensitization. Furthermore, no clear associations between mattress endotoxin levels and wheeze or atopy were found. Endotoxin in floor dust was inversely associated with atopic sensitization and wheeze, statistically significant only for atopic wheeze. Finally, a nonsignificant inverse association was observed between living room endotoxin and atopy within the non-wheezing control group. In conclusion, although our study found mostly negative results, it does suggest that endotoxin on living room floors might protect against atopic wheeze. However, this finding should be interpreted with caution due the relatively small sample size of the study and requires further confirmation.
本研究旨在评估巴勒斯坦地区喘息或致敏与螨虫、猫和狗过敏原以及细菌内毒素浓度之间的关系。一项巢式病例对照研究对110所儿童房屋的床垫和地板灰尘进行了分析，这些房屋中有报告喘息的儿童，也有未喘息的儿童。我们发现过敏原水平与喘息或特异性特应性致敏之间没有一致的关联。此外，未发现床垫内毒素水平与喘息或特应性之间有明确关联。地板灰尘中的内毒素与特应性致敏和喘息呈负相关，仅对特应性喘息具有统计学意义。最后，在非喘息对照组中，观察到客厅内毒素与特应性之间存在非显著的负相关。总之，尽管我们的研究大多得到阴性结果，但确实表明客厅地板上的内毒素可能预防特应性喘息。然而，由于研究样本量相对较小，这一发现应谨慎解读，需要进一步证实。
