Tse Kevin, Horner Anthony A
Department of Medicine and The Sam and Rose Stein Institute for Aging, University of California San Diego, La Jolla, CA 92093-0663, USA.
Semin Immunopathol. 2008 Feb;30(1):53-62. doi: 10.1007/s00281-007-0098-8. Epub 2007 Nov 8.
Environmental variables responsible for the increasing allergic disease burden observed in developed countries over the last century have yet to be adequately characterized. Meta-analyses of epidemiological studies presented in the first half of this paper demonstrate a correlation between farm-associated exposures (i.e., livestock, pets, unpasteurized milk, and endotoxin) and a reduction in allergic risk during childhood. Laboratory investigations discussed in the second half of the paper characterize the intrinsic immunostimulatory activities of living environments. Considered together, experimental findings presented herein suggest a novel paradigm by which early life home exposures to microbial products and other allergen-nonspecific immunostimulants modify allergic risk.
在过去一个世纪里，发达国家所观察到的过敏性疾病负担增加的环境变量尚未得到充分描述。本文前半部分流行病学研究的荟萃分析表明，与农场相关的接触（即家畜、宠物、未经巴氏消毒的牛奶和内毒素）与儿童期过敏风险降低之间存在关联。本文后半部分讨论的实验室研究描述了生活环境的内在免疫刺激活性。综合来看，本文所呈现的实验结果提出了一种新的模式，即生命早期在家中接触微生物产物和其他过敏原非特异性免疫刺激剂会改变过敏风险。
