Porter C V, Higgins R L, Scheel L D
Am Ind Hyg Assoc J. 1975 Mar;36(3):159-68. doi: 10.1080/0002889758507230.
A retrospective study was made of workers in a toluene disocyanate plant using an immunologic test procedure developed at the NIOSH laboratories. Case histories of 32 workers in seven response groupings are presented. Sensitization was found to correlate with the frequency and severity of significant exposures to TDI. Immunologic changes producing tolerance to TDI exposure also resulted in negative response to the antigen challenge tests. Some individuals exposed to TDI may have protective antibodies but still experience bronchoconstriction.
采用美国国家职业安全与健康研究所（NIOSH）实验室开发的免疫检测程序，对一家甲苯二异氰酸酯工厂的工人进行了一项回顾性研究。文中呈现了七个反应分组中32名工人的病历。研究发现，致敏与显著接触TDI的频率和严重程度相关。产生对TDI暴露耐受性的免疫变化也导致对抗原激发试验的阴性反应。一些接触TDI的个体可能有保护性抗体，但仍会出现支气管收缩。
