Sissener T R, Bacon N J, Friend E, Anderson D M, White R A S
The Queen's Veterinary School Hospital, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
J Small Anim Pract. 2006 Jun;47(6):312-5. doi: 10.1111/j.1748-5827.2006.00017.x.
To evaluate the effect of short duration 1 per cent clotrimazole flush when combined with 1 per cent clotrimazole cream instilled into the frontal sinuses for the treatment of nasal aspergillosis in 14 dogs.
Fourteen dogs with clinical, radiological, serological and rhinoscopic findings consistent with nasal aspergillosis were treated by frontal sinus trephination and a short, five-minute flushing of 1 per cent topical clotrimazole solution followed by a 1 per cent clotrimazole cream instilled as a depot agent.
Twelve of the 14 dogs (86 per cent) responded well to treatment and either had no clinical signs after treatment or had signs consistent with mild rhinitis during a minimum follow-up period of six months. Only one dog required multiple treatments. Treatment was well tolerated by all patients, with minimal complications.
This treatment compares favourably to previously published data using one-hour topical clotrimazole or enilconazole flushing treatment protocols. The treatment technique significantly reduced treatment time under anaesthesia.
评估1%克霉唑溶液短时间冲洗联合1%克霉唑乳膏注入额窦治疗14只犬鼻曲霉菌病的效果。
对14只临床、放射学、血清学及鼻镜检查结果符合鼻曲霉菌病的犬，行额窦环锯术，用1%克霉唑溶液进行5分钟的短时冲洗，随后注入1%克霉唑乳膏作为长效制剂。
14只犬中有12只（86%）对治疗反应良好，治疗后无临床症状，或在至少6个月的随访期内有与轻度鼻炎相符的症状。仅1只犬需要多次治疗。所有患犬对治疗耐受性良好，并发症极少。
该治疗方法与先前发表的使用1小时克霉唑局部冲洗或益康唑冲洗治疗方案的数据相比更具优势。该治疗技术显著缩短了麻醉下的治疗时间。
