Mathews K G, Davidson A P, Koblik P D, Richardson E F, Komtebedde J, Pappagianis D, Hector R F, Kass P H
Department of Surgical, School of Veterinary Medicine, University of California, Davis 95616, USA.
J Am Vet Med Assoc. 1998 Aug 15;213(4):501-6.
To examine the clinical response to topical administration of clotrimazole in dogs with nasal aspergillosis, to compare effect of surgically placed versus nonsurgically placed catheters used for administration on outcome, and to examine whether subjective scoring of computed tomographic images can predict outcome.
Retrospective case series.
60 dogs with nasal aspergillosis.
Information including signalment, history, diagnostics, treatment method, and outcome was retrieved from medical records of dogs with nasal aspergillosis treated between 1990 and 1996 at the University of California School of Veterinary Medicine or cooperating referral practices. Final outcome was determined by telephone conversations with owners and referring veterinarians. Images obtained before treatment were subjectively assessed to develop an algorithm for predicting outcome.
Clotrimazole solution (1%) was infused during a 1-hour period via catheters surgically placed in the frontal sinus and nose (27 dogs) and via nonsurgically placed catheters in the nose (18). An additional 15 dogs received 2 to 4 infusions by either route. Topical administration of clotrimazole resulted in resolution of clinical disease in 65% of dogs after 1 treatment and 87% of dogs after one or more treatments. The scoring system correctly classified dogs with unfavorable and favorable responses 71 to 78% and 79 to 93% of the time, respectively.
Topical administration of clotrimazole, using either technique, was an effective treatment for nasal aspergillosis in dogs. Use of non-invasive intranasal infusion of clotrimazole eliminated the need for surgical trephination of frontal sinuses in many dogs and was associated with fewer complications.
研究克霉唑局部给药治疗犬鼻曲霉菌病的临床反应，比较手术放置导管给药与非手术放置导管给药对治疗结果的影响，并探讨计算机断层扫描图像的主观评分是否可预测治疗结果。
回顾性病例系列研究。
60只患有鼻曲霉菌病的犬。
从1990年至1996年在加利福尼亚大学兽医学院或合作转诊机构接受治疗的犬鼻曲霉菌病病历中获取包括特征、病史、诊断、治疗方法和治疗结果等信息。通过与犬主和转诊兽医的电话沟通确定最终治疗结果。对治疗前获得的图像进行主观评估以制定预测治疗结果的算法。
通过手术放置在额窦和鼻腔的导管（27只犬）以及通过非手术放置在鼻腔的导管，在1小时内输注1%克霉唑溶液（18只犬）。另外15只犬通过任一途径接受了2至4次输注。克霉唑局部给药使65%的犬在1次治疗后临床疾病得到缓解，87%的犬在1次或多次治疗后得到缓解。评分系统分别在71%至78%和79%至93%的时间内正确分类了反应不佳和反应良好的犬。
使用任一技术进行克霉唑局部给药都是治疗犬鼻曲霉菌病的有效方法。采用无创鼻内输注克霉唑可使许多犬无需进行额窦手术钻孔，且并发症较少。
