Billen Frédéric, Guieu Liz-Valery, Bernaerts Frédérique, Mercier Elise, Lavoué Rachel, Tual Charlotte, Peeters Dominique, Clercx Cécile
Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster 20(B44), 4000 Liège, Belgium.
Can Vet J. 2010 Feb;51(2):164-8.
This study evaluated the effect of 1% bifonazole cream in the treatment of canine sino-nasal aspergillosis (SNA). The cream was instilled through perendoscopically placed catheters into the frontal sinuses and was used either as single therapy after debridement (DC) or as adjunctive therapy after 2% enilconazole infusion (DEC). Twelve dogs were treated initially with DEC: 7 and 3 of these dogs were free of disease after 1 and 2 procedures, respectively, while 2 dogs were cured after DC was used as a second procedure. Five dogs were treated with DC only: in 3 dogs with moderate disease, cure was obtained after a single procedure while, in 2 debilitated patients, cure could not be confirmed. Topical administration of 1% bifonazole cream appears as an effective therapy in SNA, either as an adjunctive therapy to enilconazole infusion or as sole therapy in moderately affected patients.
本研究评估了1%联苯苄唑乳膏治疗犬鼻窦曲霉菌病（SNA）的效果。该乳膏通过经内镜放置的导管注入额窦，在清创后单独使用（DC）或在2%益康唑输注后作为辅助治疗（DEC）。12只犬最初接受DEC治疗：其中7只和3只犬分别在1次和2次治疗后无疾病，而2只犬在第二次使用DC治疗后治愈。5只犬仅接受DC治疗：3只病情中等的犬在单次治疗后治愈，而2只体弱的犬无法确认治愈情况。局部应用1%联苯苄唑乳膏似乎是治疗SNA的有效方法，可作为益康唑输注的辅助治疗或在病情中等的患者中作为单一治疗。
