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饮酒与怀孕识别时间

Alcohol consumption and time to recognition of pregnancy.

作者信息

Edwards Erika M, Werler Martha M

机构信息

Data Coordinating Center, Boston University School of Public Health, 715 Albany St, 580, Boston, MA 02118, USA.

出版信息

Matern Child Health J. 2006 Nov;10(6):467-72. doi: 10.1007/s10995-006-0083-1.

Abstract

OBJECTIVES

Despite warnings to abstain from alcohol, American women who are or could become pregnant still drink. This study evaluates whether women who consume alcohol are at an increased risk of recognizing pregnancy later than women who do not, adjusting for confounding factors that have been associated with alcohol consumption during pregnancy.

METHODS

The sample included 863 control women from a multisite case-control study conducted from 1996 to 2002 in the United States and Canada. Telephone interviews were conducted with mothers by trained nurse interviewers who administered standardized questionnaires on demographic and reproductive factors, and pregnancy exposures.

RESULTS

Alcohol consumption was classified as none (42.0%), occasional (31.9%), regular (15.6%), and heavy (10.5%). Time to recognition of pregnancy was calculated as the date pregnancy was suspected minus the last menstrual period date (median: 31 days; range: 7-227 days). Unadjusted Cox proportional hazard models found that regular drinkers, but not heavy drinkers, had a significantly higher risk of recognizing pregnancy later than non-drinkers. However, this association went away after adjustment for demographic factors. Among women with unplanned pregnancies, heavy alcohol intake was associated with a 45% increased hazard ratio, compared to 0.80 for women with planned pregnancies; however, this finding was not statistically significant.

CONCLUSIONS

While time to pregnancy recognition did not vary among drinkers and non-drinkers, results from this study reiterate previous findings that pregnant women consume alcohol, and that drinkers share social and demographic characteristics that could be used to target public health interventions.

摘要

目的

尽管有戒酒的警告,但美国已怀孕或可能怀孕的女性仍在饮酒。本研究评估饮酒女性与不饮酒女性相比,在识别怀孕方面是否存在更高的风险,并对与孕期饮酒相关的混杂因素进行调整。

方法

样本包括1996年至2002年在美国和加拿大进行的一项多中心病例对照研究中的863名对照女性。由经过培训的护士访谈员对母亲进行电话访谈,这些访谈员会发放关于人口统计学和生殖因素以及孕期暴露情况的标准化问卷。

结果

饮酒情况分为不饮酒(42.0%)、偶尔饮酒(31.9%)、经常饮酒(15.6%)和大量饮酒(10.5%)。怀孕识别时间计算为怀疑怀孕日期减去末次月经日期(中位数:31天;范围:7 - 227天)。未调整的Cox比例风险模型发现,经常饮酒者而非大量饮酒者,与不饮酒者相比,识别怀孕的风险显著更高。然而,在对人口统计学因素进行调整后,这种关联消失了。在意外怀孕的女性中,与计划怀孕的女性相比,大量饮酒与风险比增加45%相关;然而,这一发现无统计学意义。

结论

虽然饮酒者和不饮酒者在怀孕识别时间上没有差异,但本研究结果重申了先前的发现,即孕妇饮酒,且饮酒者具有可用于针对公共卫生干预措施的社会和人口统计学特征。

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