Narod S A, Feunteun J, Lynch H T, Watson P, Conway T, Lynch J, Lenoir G M
Centre for Human Genetics, McGill University, Montreal, Canada.
Lancet. 1991 Jul 13;338(8759):82-3. doi: 10.1016/0140-6736(91)90076-2.
Familial breast cancer has been linked to the D17S74 locus on chromosome 17q. To confirm this finding and to investigate whether ovarian cancer is also linked to this locus, five large families with a hereditary predisposition to cancer of the breast and ovary were investigated. Three families were positive for linkage. For the largest family the lod score was 2.72. These findings suggest that the chromosomal region 17q12-q23, previously shown to contain a gene for early-onset breast cancer, is also associated with a proportion of hereditary ovarian cancers.
家族性乳腺癌与17号染色体长臂上的D17S74位点有关。为了证实这一发现并研究卵巢癌是否也与该位点有关，对五个有乳腺癌和卵巢癌遗传易感性的大家族进行了调查。三个家族连锁检测呈阳性。对于最大的家族，连锁值为2.72。这些发现表明，先前显示含有早发性乳腺癌基因的17q12-q23染色体区域，也与一部分遗传性卵巢癌有关。
