使用鬼针草提取物对正常人红细胞进行氧化损伤防护。
Protection from oxidative damage using Bidens pilosa extracts in normal human erythrocytes.
作者信息
Yang Hsin-Ling, Chen Ssu-Ching, Chang Nai-Wen, Chang Jia-Ming, Lee Mei-Ling, Tsai Pei-Chuan, Fu Han-Hsuan, Kao Wei-Wan, Chiang Hsiao-Chi, Wang Hsuan-Hui, Hseu You-Cheng
机构信息
Institute of Nutrition, China Medical University, Taichung, Taiwan.
出版信息
Food Chem Toxicol. 2006 Sep;44(9):1513-21. doi: 10.1016/j.fct.2006.04.006. Epub 2006 Apr 25.
Bidens pilosa (B. pilosa) is well known in Taiwan as a traditional Chinese medicine. The purpose of this study was to evaluate the ability of both the ethanol (EtOH) and ethylacetate/ethanol (EA/EtOH) extracts from the whole B. pilosa plant, to protect normal human erythrocytes against oxidative damage in vitro. It was determined that the oxidative hemolysis and lipid/protein peroxidation of erythrocytes induced by the aqueous peroxyl radical [2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH)] were suppressed by both EtOH (50-150 microg/ml) and EA/EtOH (25-75 microg/ml) extracts of B. pilosa in concentration- and time-dependent manners. B. pilosa extracts also prevented the decline of superoxide dismutase (SOD) activity and the depletion of cytosolic glutathione (GSH) and ATP in erythrocytes. These results imply that B. pilosa may have protective antioxidant properties.
咸丰草在台湾作为一种传统中药而广为人知。本研究的目的是评估咸丰草全株的乙醇提取物（EtOH）和乙酸乙酯/乙醇提取物（EA/EtOH）在体外保护正常人红细胞免受氧化损伤的能力。结果表明，由过氧自由基[2,2'-偶氮二（2-脒基丙烷）二盐酸盐（AAPH）]诱导的红细胞氧化溶血和脂质/蛋白质过氧化，均受到咸丰草EtOH提取物（50-150微克/毫升）和EA/EtOH提取物（25-75微克/毫升）的抑制，且呈浓度和时间依赖性。咸丰草提取物还能防止红细胞中超氧化物歧化酶（SOD）活性的下降以及胞质谷胱甘肽（GSH）和ATP的消耗。这些结果表明，咸丰草可能具有保护性抗氧化特性。
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