Redline Raymond W
Department of Pathology, University Hospitals of Cleveland, OH 44106, USA.
Clin Perinatol. 2006 Jun;33(2):503-16. doi: 10.1016/j.clp.2006.03.007.
Recent classification systems of cerebral palsy call for an assessment of the timing and etiology of brain injury. The placenta is an underused resource for addressing these important questions. An expert assessment of the placental pathology can provide temporally and mechanistically specific data not available from any other source. Key concepts for an understanding of the role of placental pathology are the "sentinel lesion," the high prevalence of thromboinflammatory lesions affecting large fetal placental vessels, the significance of underlying placental reserve, and the realization that placental findings can serve as markers for processes occurring in the mother or fetus.
近期的脑瘫分类系统要求对脑损伤的时间和病因进行评估。胎盘是解决这些重要问题时未得到充分利用的资源。对胎盘病理学进行专家评估可提供从其他任何来源都无法获得的具有时间和机制特异性的数据。理解胎盘病理学作用的关键概念包括“哨兵病变”、影响胎儿胎盘大血管的血栓炎症性病变的高患病率、潜在胎盘储备的重要性，以及认识到胎盘检查结果可作为母亲或胎儿中发生的过程的标志物。
