Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA.
Clin Perinatol. 2010 Jun;37(2):355-74. doi: 10.1016/j.clp.2010.03.002.
Intrauterine infection is a unique pathologic process that raises the risk for early-onset neonatal sepsis (EONS). By acting synergistically with prematurity, EONS increases the risk for adverse neonatal outcomes, including intraventricular hemorrhage and cerebral palsy. Although several pathways for the pathogenesis of fetal damage have been proposed, the basic molecular mechanisms that modulate these events remain incompletely understood. Discovery of clinically and biologically relevant biomarkers able to reveal key pathogenic pathways and predict pregnancies at risk for antenatal fetal damage is a priority. Proteomics provides a unique opportunity to fill this gap.
宫内感染是一种独特的病理过程，会增加早发性新生儿败血症（EONS）的风险。EONS 通过与早产协同作用，增加了不良新生儿结局的风险，包括脑室出血和脑瘫。虽然已经提出了几种胎儿损伤发病机制的途径，但调节这些事件的基本分子机制仍不完全清楚。发现具有临床和生物学相关性的生物标志物，以揭示关键的致病途径，并预测有产前胎儿损伤风险的妊娠，是当务之急。蛋白质组学提供了一个独特的机会来填补这一空白。
