Eriksen Bondevik Bjørn, Kåre Dotterud Lars
Dr Bondeviks Dermatological Clinic, Oslo, Norway.
J Dermatolog Treat. 2006;17(2):82-5. doi: 10.1080/09546630600621946.
To investigate whether dietary supplementation with polyunsaturated fatty acids (PUFA) of the omega 3 series (n-3 PUFA: 18:3, n-3; 20:5, n-3; and 22:6, n-3), the omega 6 series (n-6 PUFA: 18:3, n-6), vitamins and minerals have a clinical effect on atopic dermatitis.
A total of 19 patients aged 17-43 years with moderate to severe atopic dermatitis participated in an open trial of high oral doses of n-3 and n-6 PUFA in dry form (powder) or omega 3,6,9 fatty acid capsules, vitamin E tablets (d-alpha-tocopherol), zinc solution or tablets, and multivitamin capsules daily for 16 weeks.
The mean SCORAD improved in 14 of 17 patients by more than 50% after 8 weeks and 16 weeks of treatment (p<0.01 and p<0.001, respectively).
The open nature of this trial and the small number of subjects are major limitations of this study. The possible role of dietary omega 3 and 6 fatty acids in the treatment of atopic dermatitis should be tested more extensively in a double-blind trial using high doses of antioxidants combined with PUFA.
研究补充ω-3系列多不饱和脂肪酸（PUFA：18:3，n-3；20:5，n-3；22:6，n-3）、ω-6系列多不饱和脂肪酸（n-6 PUFA：18:3，n-6）、维生素和矿物质对特应性皮炎是否具有临床疗效。
共有19名年龄在17至43岁之间的中重度特应性皮炎患者参与了一项开放试验，他们每天口服高剂量的干燥形式（粉末状）的n-3和n-6 PUFA或ω-3,6,9脂肪酸胶囊、维生素E片（d-α-生育酚）、锌溶液或片剂以及多种维生素胶囊，持续16周。
17名患者中有14名在治疗8周和16周后平均SCORAD改善超过50%（分别为p<0.01和p<0.001）。
本试验的开放性和受试者数量少是本研究的主要局限性。膳食中ω-3和ω-6脂肪酸在特应性皮炎治疗中的可能作用应在使用高剂量抗氧化剂联合PUFA的双盲试验中进行更广泛的测试。
