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随机对照试验采用维生素 E 和 D 补充剂治疗特应性皮炎。

Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.

机构信息

Department of Nutrition and Biochemistry, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

J Dermatolog Treat. 2011 Jun;22(3):144-50. doi: 10.3109/09546630903578566. Epub 2010 Jul 24.

DOI:10.3109/09546630903578566
PMID:20653487
Abstract

BACKGROUND

Atopic dermatitis is a chronically relapsing, highly pruritic and inflammatory skin disease. This study was done to assess the effects of vitamins D and E supplementation on the clinical manifestation of atopic dermatitis.

METHODS

Forty-five atopic dermatitis patients were included in a randomized, double-blind, placebo-controlled trial. They were randomly divided into four groups and treated for 60 days: group P (n = 11), vitamins D and E placebos; group D (n = 12), 1600 IU vitamin D(3) plus vitamin E placebo; group E (n = 11), 600 IU synthetic all-rac-α-tocopherol plus vitamin D placebo; and group DE (n = 11), 1600 IU vitamin D(3) plus 600 IU synthetic all-rac-α-tocopherol. Serum 25(OH) vitamin D and plasma α-tocopherol were determined before and after the trial. The clinical improvement was evaluated with SCORing Atopic Dermatitis (SCORAD). Data were analyzed by analysis of variance (ANOVA) and Kruskal-Wallis tests.

RESULTS

SCORAD was reduced after 60 days in groups D, E and DE by 34.8%, 35.7% and 64.3%, respectively (p = 0.004). Objective SCORAD also showed significant improvement. There was a positive correlation between SCORAD and intensity, objective, subjective and extent (p < 0.001). We found a significant negative association between plasma α-tocopherol and SCORAD, intensity, objective and extent (p = 0.02).

CONCLUSION

This study supports the contributing and beneficial effects of vitamins D and E in the treatment of atopic dermatitis.

摘要

背景

特应性皮炎是一种慢性复发性、高度瘙痒和炎症性皮肤病。本研究旨在评估维生素 D 和 E 补充剂对特应性皮炎临床表现的影响。

方法

45 例特应性皮炎患者被纳入一项随机、双盲、安慰剂对照试验。他们被随机分为四组,治疗 60 天:P 组(n = 11),给予维生素 D 和 E 安慰剂;D 组(n = 12),给予 1600 IU 维生素 D3 加维生素 E 安慰剂;E 组(n = 11),给予 600 IU 合成全-rac-α-生育酚加维生素 D 安慰剂;和 DE 组(n = 11),给予 1600 IU 维生素 D3 加 600 IU 合成全-rac-α-生育酚。试验前后测定血清 25(OH) 维生素 D 和血浆 α-生育酚。采用 SCORing 特应性皮炎(SCORAD)评估临床改善情况。数据采用方差分析(ANOVA)和 Kruskal-Wallis 检验进行分析。

结果

D 组、E 组和 DE 组治疗 60 天后 SCORAD 分别降低 34.8%、35.7%和 64.3%(p = 0.004)。客观 SCORAD 也显示出显著改善。SCORAD 与强度、客观、主观和范围呈正相关(p < 0.001)。我们发现血浆 α-生育酚与 SCORAD、强度、客观和范围呈显著负相关(p = 0.02)。

结论

本研究支持维生素 D 和 E 在特应性皮炎治疗中的辅助和有益作用。

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