ω-3 脂肪酸与皮肤疾病
Omega 3 Fatty Acid and Skin Diseases.
机构信息
Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan.
出版信息
Front Immunol. 2021 Feb 5;11:623052. doi: 10.3389/fimmu.2020.623052. eCollection 2020.
Abstract
Humans are exposed to various external environmental factors. Food intake is one of the most influential factors impacting daily lifestyle. Among nutrients obtained from foods, omega-3 polyunsaturated fatty acids (PUFAs) have various beneficial effects on inflammatory diseases. Furthermore, omega-3 PUFA metabolites, including resolvins, are known to demonstrate strong anti-inflammatory effects during allergic and inflammatory diseases; however, little is known regarding the actual impact of these metabolites on skin diseases. In this review, we focused on metabolites that have strong anti-inflammatory actions in various inflammatory diseases, as well as those that present antitumor actions in malignancies, in addition to the actual effect of omega-3 PUFA metabolites on various cells.
摘要
人类会接触到各种外部环境因素。饮食是影响日常生活方式的最具影响力因素之一。在从食物中获得的营养素中，ω-3 多不饱和脂肪酸（PUFA）对炎症性疾病具有多种有益作用。此外，已知 ω-3 PUFA 代谢物，包括 resolvins，在过敏和炎症性疾病中表现出强烈的抗炎作用；然而，对于这些代谢物对皮肤病的实际影响知之甚少。在这篇综述中，我们重点介绍了在各种炎症性疾病中具有强烈抗炎作用的代谢物，以及在恶性肿瘤中具有抗肿瘤作用的代谢物，以及 ω-3 PUFA 代谢物对各种细胞的实际作用。
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