Villacorta Humberto, Bortolotto Luiz Aparecido, Arteaga Edmundo, Mady Charles
Heart Institute (InCor), University of São Paulo, Medical School, São Paulo, Brazil.
J Negat Results Biomed. 2006 Jun 12;5:9. doi: 10.1186/1477-5751-5-9.
Experimental studies demonstrate that infection with trypanosoma cruzi causes vasculitis. The inflammatory lesion process could hypothetically lead to decreased distensibility of large and small arteries in advanced Chagas' disease. We tested this hypothesis.
We evaluated carotid-femoral pulse-wave velocity (PWV) in 53 Chagas' disease patients compared with 31 healthy volunteers (control group). The 53 patients were classified into 3 groups: 1) 16 with indeterminate form of Chagas' disease; 2) 18 with Chagas' disease, electrocardiographic abnormalities, and normal systolic function; 3) 19 with Chagas' disease, systolic dysfunction, and mild-to-moderate congestive heart failure. No difference was noted between the 4 groups regarding carotid-femoral PWV (8.4 +/- 1.1 vs 8.2 +/- 1.5 vs 8.2 +/- 1.4 vs 8.7 +/- 1.6 m/s, P = 0.6) or pulse pressure (39.5 +/- 7.6 vs 39.3 +/- 8.1 vs 39.5 +/- 7.4 vs 39.7 +/- 6.9 mm Hg, P = 0.9). A positive, significant, similar correlation occurred between PWV and age in patients with Chagas' disease (r = 0.42, P = 0.002), in controls (r = 0.48, P = 0.006), and also between PWV and systolic blood pressure in both groups (patients with Chagas' disease, r = 0.38, P = 0.005; healthy subjects, r = 0.36, P = 0.043).
Carotid femoral pulse-wave velocity is not modified in patients with Chagas' disease, suggesting that elastic properties of large arteries are not affected in this disorder.
实验研究表明，克氏锥虫感染可导致血管炎。理论上，炎症病变过程可能会导致晚期恰加斯病患者的大动脉和小动脉扩张性降低。我们对这一假设进行了验证。
我们评估了53例恰加斯病患者的颈股脉搏波速度（PWV），并与31名健康志愿者（对照组）进行比较。53例患者分为3组：1）16例为恰加斯病不确定型；2）18例患有恰加斯病、心电图异常且收缩功能正常；3）19例患有恰加斯病、收缩功能障碍以及轻度至中度充血性心力衰竭。四组之间在颈股PWV（8.4±1.1 vs 8.2±1.5 vs 8.2±1.4 vs 8.7±1.6 m/s，P = 0.6）或脉压（39.5±7.6 vs 39.3±8.1 vs 39.5±7.4 vs 39.7±6.9 mmHg，P = 0.9）方面未发现差异。恰加斯病患者中，PWV与年龄之间存在显著的正相关（r = 0.42，P = 0.002），对照组中也是如此（r = 0.48，P = 0.006），并且两组中PWV与收缩压之间也存在类似的相关性（恰加斯病患者，r = 0.38，P = 0.005；健康受试者，r = 0.36，P = 0.043）。
恰加斯病患者的颈股脉搏波速度未发生改变，这表明该疾病不会影响大动脉的弹性特性。
