Yu W-C, Chuang S-Y, Lin Y-P, Chen C-H
Department of Internal Medicine, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan.
J Hum Hypertens. 2008 Jan;22(1):24-31. doi: 10.1038/sj.jhh.1002259. Epub 2007 Jun 28.
Carotid-femoral pulse wave velocity (cf-PWV) is a validated marker of arterial stiffening over the central arteries. Brachial-ankle pulse wave velocity (ba-PWV) integrates the mechanical properties from both the central and peripheral arteries and may be more representative than cf-PWV as arterial load for left ventricle (LV). We compared ba-PWV with cf-PWV for the association of cardiovascular structure and function in 320 subjects with various degrees of abnormality in cardiac structure and function. ba-PWV (by oscillometric technique) and cf-PWV (by tonometric technique) were measured simultaneously, and were highly correlated (r=0.79, P<0.001). Both ba-PWV and cf-PWV were significantly correlated with LV mass, but the correlation was better with ba-PWV (r=0.29 vs r=0.22, P=0.0219). While ba-PWV and cf-PWV were similarly significantly correlated with LV end-systolic elastance and mitral E/A ratio, ba-PWV had better correlation with isovolumic relaxation constant (r=0.34 vs r=0.27, P=0.0202) than cf-PWV. In addition, the correlation was also significantly stronger with ba-PWV than with cf-PWV for other indices of arterial stiffness, including carotid incremental modulus (r=0.59 vs 0.50, P=0.0013), effective arterial elastance (r=0.41 vs r=0.33, P=0.0081) and carotid augmentation index (r=0.38 vs r=0.32, P=0.0368). In conclusion, ba-PWV correlates better with LV mass and diastolic function and other indices of arterial function than cf-PWV, probably because ba-PWV encompasses a greater territory of arterial tree than cf-PWV.
颈股脉搏波速度（cf-PWV）是一种经过验证的反映中心动脉僵硬度的指标。臂踝脉搏波速度（ba-PWV）综合了中心动脉和外周动脉的力学特性，作为左心室（LV）的动脉负荷，可能比cf-PWV更具代表性。我们比较了320例心脏结构和功能存在不同程度异常的受试者的ba-PWV和cf-PWV与心血管结构和功能的相关性。同时测量ba-PWV（采用示波技术）和cf-PWV（采用张力测量技术），二者高度相关（r=0.79，P<0.001）。ba-PWV和cf-PWV均与左心室质量显著相关，但与ba-PWV的相关性更好（r=0.29对r=0.22，P=0.0219）。虽然ba-PWV和cf-PWV与左心室收缩末期弹性和二尖瓣E/A比值同样显著相关，但ba-PWV与等容舒张常数的相关性优于cf-PWV（r=0.34对r=0.27，P=0.0202）。此外，对于其他动脉僵硬度指标，包括颈动脉增量模量（r=0.59对0.50，P=0.0013）、有效动脉弹性（r=0.41对r=0.33，P=0.0081）和颈动脉增强指数（r=0.38对r=0.32，P=0.0368），ba-PWV的相关性也显著强于cf-PWV。总之，ba-PWV与左心室质量、舒张功能及其他动脉功能指标的相关性优于cf-PWV，可能是因为ba-PWV所涵盖的动脉范围比cf-PWV更广。
