• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

以急性间质性肺炎为首发表现的抗合成酶综合征：1例非典型病例

Acute interstitial pneumonia as first presentation of anti-synthetase syndrome: an atypical case.

作者信息

Jan Kalimullah, Sriranganathan Melonie Kannamma

机构信息

Department of Medicine, Changi General Hospital, Singapore.

出版信息

Oxf Med Case Reports. 2018 Apr 4;2018(4):omy003. doi: 10.1093/omcr/omy003. eCollection 2018 Apr.

DOI:10.1093/omcr/omy003
PMID:29644083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5887849/
Abstract

Anti-synthetase syndrome is characterized by myositis associated with interstitial lung disease (ILD), the usual pattern of ILD being non-specific interstitial pneumonia type or usual interstitial pneumonia. We report a case of anti-synthetase syndrome presenting as acute interstitial pneumonia which is reported only once before. With this case, we emphasize the need to consider anti-synthetase syndrome even in patients presenting with acute onset ILD. Physicians should raise their index of suspicion in this clinical context as timely diagnosis, early treatment, and a multidisciplinary approach is paramount for optimal care of these patients.

摘要

抗合成酶综合征的特征是肌炎伴发间质性肺疾病（ILD），ILD的常见类型为非特异性间质性肺炎或普通间质性肺炎。我们报告了一例表现为急性间质性肺炎的抗合成酶综合征病例，此前仅有一次相关报道。通过该病例，我们强调即使是急性起病的ILD患者也需要考虑抗合成酶综合征。在这种临床情况下，医生应提高警惕，因为及时诊断、早期治疗以及多学科方法对于这些患者的最佳治疗至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f83/5887849/5c49b42c6e07/omy003f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f83/5887849/5c49b42c6e07/omy003f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f83/5887849/5c49b42c6e07/omy003f01.jpg

相似文献

1
Acute interstitial pneumonia as first presentation of anti-synthetase syndrome: an atypical case.以急性间质性肺炎为首发表现的抗合成酶综合征：1例非典型病例
Oxf Med Case Reports. 2018 Apr 4;2018(4):omy003. doi: 10.1093/omcr/omy003. eCollection 2018 Apr.
2
Antisynthetase syndrome: An under-recognized cause of interstitial lung disease.抗合成酶综合征：间质性肺疾病的一个未被充分认识的病因。
Lung India. 2016 Jan-Feb;33(1):20-6. doi: 10.4103/0970-2113.173055.
3
Clinical, radiological, and pathological features of anti-asparaginyl tRNA synthetase antibody-related interstitial lung disease.抗天冬酰胺酰tRNA合成酶抗体相关间质性肺疾病的临床、影像学及病理特征
Respir Investig. 2020 May;58(3):196-203. doi: 10.1016/j.resinv.2019.12.003. Epub 2020 Feb 22.
4
A Multidisciplinary Evaluation Helps Identify the Antisynthetase Syndrome in Patients Presenting as Idiopathic Interstitial Pneumonia.多学科评估有助于在表现为特发性间质性肺炎的患者中识别抗合成酶综合征。
J Rheumatol. 2016 May;43(5):887-92. doi: 10.3899/jrheum.150966. Epub 2016 Mar 1.
5
Long-term clinical course of anti-glycyl tRNA synthetase (anti-EJ) antibody-related interstitial lung disease pathologically proven by surgical lung biopsy.经外科肺活检病理证实的抗甘氨酰tRNA合成酶（抗EJ）抗体相关间质性肺疾病的长期临床病程
BMC Pulm Med. 2016 Dec 1;16(1):168. doi: 10.1186/s12890-016-0325-y.
6
Acute Onset Anti-Synthetase Syndrome With Pericardial Effusion and Non-Specific Interstitial Pneumonia.急性起病的抗合成酶综合征伴心包积液和非特异性间质性肺炎。
J Clin Med Res. 2016 Sep;8(9):683-7. doi: 10.14740/jocmr2631w. Epub 2016 Jul 30.
7
[Clinical and radiological features of adult patients with different antisynthetase syndrome based on serum anti-aminoacyl-tRNA synthetase antibody type].[基于血清抗氨酰tRNA合成酶抗体类型的不同抗合成酶综合征成年患者的临床和放射学特征]
Zhonghua Jie He He Hu Xi Za Zhi. 2017 Dec 12;40(12):919-924. doi: 10.3760/cma.j.issn.1001-0939.2017.12.011.
8
The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies.伴有抗氨酰tRNA合成酶抗体的间质性肺疾病的长期预后。
Respir Med. 2017 Jun;127:57-64. doi: 10.1016/j.rmed.2017.04.007. Epub 2017 Apr 15.
9
The pulmonary histopathology of anti-KS transfer RNA synthetase syndrome.抗氨酰tRNA合成酶综合征的肺部组织病理学
Arch Pathol Lab Med. 2015 Jan;139(1):122-5. doi: 10.5858/arpa.2013-0667-OA.
10
Anti-synthetase syndrome in a patient with recurrent episodes of pulmonary embolism: a case report.一名复发性肺栓塞患者的抗合成酶综合征：病例报告
J Community Hosp Intern Med Perspect. 2020 Jun 14;10(3):255-257. doi: 10.1080/20009666.2020.1769421.

引用本文的文献

1
Acute hypoxic respiratory failure secondary to antisynthetase syndrome: A case report and review of literature.抗合成酶综合征继发急性低氧性呼吸衰竭：一例病例报告及文献复习
Respir Med Case Rep. 2019 Feb 21;26:288-291. doi: 10.1016/j.rmcr.2019.02.009. eCollection 2019.

本文引用的文献

1
Clinical and pathologic differences in interstitial lung disease based on antisynthetase antibody type.基于抗合成酶抗体类型的间质性肺疾病的临床和病理差异
Respir Med. 2014 Oct;108(10):1542-8. doi: 10.1016/j.rmed.2014.09.003. Epub 2014 Sep 18.
2
The clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome.与肌炎特异性和相关自身抗体相关的临床表型：一项重新审视所谓的抗合成酶综合征的荟萃分析。
Autoimmun Rev. 2014 Sep;13(9):883-91. doi: 10.1016/j.autrev.2014.03.004. Epub 2014 Apr 3.
3
Anti-PL-7 (anti-threonyl-tRNA synthetase) antisynthetase syndrome: clinical manifestations in a series of patients from a European multicenter study (EUMYONET) and review of the literature.
抗PL-7（抗苏氨酰tRNA合成酶）抗合成酶综合征：来自一项欧洲多中心研究（EUMYONET）的一系列患者的临床表现及文献综述
Medicine (Baltimore). 2012 Jul;91(4):206-211. doi: 10.1097/MD.0b013e318260977c.
4
Antisynthetase syndrome.抗合成酶综合征。
Curr Rheumatol Rep. 2011 Jun;13(3):175-81. doi: 10.1007/s11926-011-0176-8.
5
Myositis-related interstitial lung disease and antisynthetase syndrome.肌炎相关性间质性肺病和抗合成酶综合征。
J Bras Pneumol. 2011 Jan-Feb;37(1):100-9. doi: 10.1590/s1806-37132011000100015.
6
Clinical features and prognosis of patients with idiopathic inflammatory myopathies and anti-Jo-1 antibodies.特发性炎性肌病合并抗Jo-1抗体患者的临床特征及预后
Autoimmunity. 2006 May;39(3):243-7. doi: 10.1080/08916930600623767.
7
Polymyositis and dermatomyositis.多发性肌炎和皮肌炎。
Lancet. 2003 Sep 20;362(9388):971-82. doi: 10.1016/S0140-6736(03)14368-1.
8
Hamman-Rich syndrome revisited.再探哈曼-里奇综合征。
Mayo Clin Proc. 1990 Dec;65(12):1538-48. doi: 10.1016/s0025-6196(12)62187-9.