Meng Bo, Wang Jing, Zhu Ning, Meng Qing-Yuan, Cui Fu-Zhai, Xu Ying-Xin
Department of Materials Science & Engineering, Tsinghua University, Beijing, 100084, Peoples Republic of China.
J Mater Sci Mater Med. 2006 Jul;17(7):611-7. doi: 10.1007/s10856-006-9223-9.
Biodegradable stents have advantages for the treatment of benign and malignant biliary stricture, especially eliminating the need for stent removal. In our present work, helical poly-l-lactic acids (PLLA) stent was fabricated and evaluated in vivo and in vitro. For in vivo study, bile duct injury canine models were made by transection of common bile ducts. Duct to duct anastomosis was done with helical PLLA biodegradable stents. Scanning electron microscopy (SEM) and histopathology were performed after three months. For In vitro study, sludge attachment assessment was performed. Polyethylene (PE) and PLLA membranes were immersed in human bile for two months. The samples were taken out and characterized by SEM. Self-expanding property of the helical stent was tested in 37 degrees Celsius water. The results demonstrate that the biodegradable stent had not only good biocompatibility, but also self-clearing effect to clear the attached sludge away. The self-expanding property facilitated stent implantation and also suggested possibility to be implanted endoscopically.
可生物降解支架在治疗良性和恶性胆管狭窄方面具有优势，尤其是无需取出支架。在我们目前的工作中，制备了螺旋聚左旋乳酸（PLLA）支架并进行了体内和体外评估。对于体内研究，通过横断胆总管制作胆管损伤犬模型。使用螺旋PLLA可生物降解支架进行端端吻合。三个月后进行扫描电子显微镜（SEM）和组织病理学检查。对于体外研究，进行了污泥附着评估。将聚乙烯（PE）和PLLA膜浸入人胆汁中两个月。取出样品并通过SEM进行表征。在37摄氏度的水中测试了螺旋支架的自膨胀性能。结果表明，可生物降解支架不仅具有良好的生物相容性，而且具有自清除作用，可清除附着的污泥。自膨胀性能便于支架植入，也提示了内镜植入的可能性。
