Metabolites of fungi & actinomycetes active against mosquito larvae.

Extracellular secondary metabolites from 350 fungi and 94 actinomycetes were screened for larvicidal activity against Culex quinquefasciatus, Anopheles stephensi and Aedes aegypti. Of them, 133 fungal metabolites and 35 from actinomycetes were active. Two from Streptomyces sp. and one from Paecilomyces sp. were highly active with LC50 value of 1-3 microliters/ml. The metabolites were more toxic to C. quinquefasciatus than to A. stephensi or Ae. aegypti larvae.