West Brett-J, Jensen C-Jarakae, Westendorf Johannes
Research and Development Department, Tahitian Noni International, American Fork, UT 84003, USA.
World J Gastroenterol. 2006 Jun 14;12(22):3616-9. doi: 10.3748/wjg.v12.i22.3616.
Noni juice (Morinda citrifolia) has been approved for use as a safe food within the European Union, following a review of safety. Since approval, three cases of acute hepatitis in Austrian noni juice consumers have been published, where a causal link is suggested between the liver dysfunction and ingestion of anthraquinones from the plant. Measurements of liver function in a human clinical safety study of TAHITIAN NONI Juice, as well as subacute and subchronic animal toxicity tests revealed no evidence of adverse liver effects at doses many times higher than those reported in the case studies. Additionally, M. citrifolia anthraquinones occur in the fruit in quantities too small to be of any toxicological significance. Further, these do not have chemical structures capable of being reduced to reactive anthrone radicals, which were implicated in previous cases of herbal hepototoxicity. The available data reveals no evidence of liver toxicity.
在经过安全性审查后，诺丽果汁（海巴戟）已被欧盟批准为安全食品。自获批以来，奥地利已公布了3例饮用诺丽果汁的急性肝炎病例，这些病例表明肝功能障碍与摄入该植物中的蒽醌之间存在因果关系。在一项关于塔希提诺丽果汁的人体临床安全性研究中对肝功能的测量，以及亚急性和亚慢性动物毒性试验表明，在剂量比病例研究中报告的剂量高出许多倍的情况下，没有证据表明对肝脏有不良影响。此外，海巴戟中的蒽醌在果实中的含量极低，不具有任何毒理学意义。此外，这些蒽醌的化学结构无法还原为具有反应性的蒽酮自由基，而此前的草药肝毒性病例中涉及到了这种自由基。现有数据表明没有肝毒性的证据。
