从地衣内生真菌微球壳菌属菌株BCC 3050中分离得到的前乌苏酸的抗分枝杆菌、抗疟原虫及细胞毒性活性评价

Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050.

作者信息

Seephonkai Prapairat, Isaka Masahiko, Kittakoop Prasat, Palittapongarnpim Prasit, Kamchonwongpaisan Sumalee, Tanticharoen Morakot, Thebtaranonth Yodhathai

机构信息

Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.

出版信息

Planta Med. 2002 Jan;68(1):45-8. doi: 10.1055/s-2002-20055.

DOI:10.1055/s-2002-20055

PMID:11842326

Abstract

A new preussomerin isomer, 3'-O-demethylpreussomerin I, five known preussomerins E - I, and two known deoxypreussomerins, deoxypreussomerin A and bipendensin (palmarumycin C11), were isolated from a lichenicolous fungus Microsphaeropsis sp. BCC 3050. These structures were elucidated by spectroscopic methods, especially 1D- and 2D-NMR. The preussomerins were evaluated for their antimycobacterial and antiplasmodial activities as well as cytotoxicity against KB, BC-1 and vero cell lines.

摘要

从一种地衣内生真菌微小球壳菌属Microsphaeropsis sp. BCC 3050中分离出一种新的前乌斯莫菌素异构体3'-O-去甲基前乌斯莫菌素I、五种已知的前乌斯莫菌素E - I以及两种已知的脱氧前乌斯莫菌素，脱氧前乌斯莫菌素A和双悬菌素（棕榈霉素C11）。这些结构通过光谱方法，尤其是一维和二维核磁共振进行了阐明。对前乌斯莫菌素的抗分枝杆菌和抗疟原虫活性以及对KB、BC-1和vero细胞系的细胞毒性进行了评估。