Asgharian B, Price O T
CIIT Centers for Health Research, Durham, North Carolina 27709, USA.
Inhal Toxicol. 2006 Sep;18(10):795-801. doi: 10.1080/08958370600748687.
Realistic descriptions of lung geometry and physiology are the primary determinants of accurate predictions of inhaled particle deposition and distribution in the human lung. While there have been considerable efforts devoted to geometry reconstruction, little attention has been given to lung ventilation as applied to particle deposition applications. Models of lung ventilation based on pressure differential between extrathoracic airways and the pleural cavity were developed and used to calculate lobar and regional deposition of particles in the human lung. Local airflow in the lung varied in accordance with regional physiological properties. Calculations showed that airflow rate entering each lobe was different for compliant and noncompliant lung models and similar for uniform and nonuniform lung expansions. Regional particle deposition predictions were almost identical between the two compliance models. However, differences in lobar depositions were observed. The coupled lung ventilation and deposition models can be used in site-specific deposition predictions of inhaled particles in the human lungs.
对肺部几何结构和生理学的真实描述是准确预测人类肺部吸入颗粒沉积和分布的主要决定因素。虽然在几何结构重建方面已经付出了相当大的努力，但对于应用于颗粒沉积应用的肺通气却很少关注。基于胸外气道与胸膜腔之间的压差建立了肺通气模型，并用于计算人类肺部颗粒的叶和区域沉积。肺内局部气流根据区域生理特性而变化。计算表明，对于顺应性和非顺应性肺模型，进入每个叶的气流速率不同，而对于均匀和非均匀肺扩张，气流速率相似。两种顺应性模型之间的区域颗粒沉积预测几乎相同。然而，观察到叶沉积存在差异。耦合的肺通气和沉积模型可用于人类肺部吸入颗粒的特定部位沉积预测。
