Blutt Sarah E, Fenaux Martijn, Warfield Kelly L, Greenberg Harry B, Conner Margaret E
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
J Virol. 2006 Jul;80(13):6702-5. doi: 10.1128/JVI.00329-06.
Rotavirus circulates extraintestinally in animals used as models for rotavirus infection and in children. Rotavirus infection in mice was used to define host or viral factors that affect rotavirus viremia. Antigenemia was observed with homologous and heterologous rotaviruses, and neither age nor mouse strain genetics altered the occurrence of rotavirus antigenemia or viremia. Rotavirus RNA and infectious virus were present in sera and associated with the plasma fraction of blood in all infected mice. These findings indicate that antigenemia/viremia occurs routinely in rotavirus infections and imply that infectious rotavirus has access to any extraintestinal cell within contact of blood.
轮状病毒在用作轮状病毒感染模型的动物以及儿童体内在肠道外循环。小鼠的轮状病毒感染被用于确定影响轮状病毒血症的宿主或病毒因素。观察到同源和异源轮状病毒均可引起抗原血症，年龄和小鼠品系遗传学均未改变轮状病毒抗原血症或病毒血症的发生情况。在所有受感染小鼠的血清中均存在轮状病毒RNA和传染性病毒，且与血液的血浆部分相关。这些发现表明，抗原血症/病毒血症在轮状病毒感染中经常发生，这意味着传染性轮状病毒可以接触到血液所及的任何肠道外细胞。
