del Pino Mariana, Bauer Gabriela, González Pena Hebe, Grenoville Mario, Lejarraga Horacio
Growth and Development, Garrahan Hospital, Combate de los Pozos 1881 (1245), Buenos Aires, Argentina.
Eur J Pediatr. 2006 Dec;165(12):845-9. doi: 10.1007/s00431-006-0179-z. Epub 2006 Jun 15.
Acute lower respiratory infection due to adenovirus is an important cause of chronic lung disease (CLD) in infants. The objectives of this paper is to describe growth in the height and weight of children with post-viral chronic lung disease (PVCLD) and to relate it with associated variables (invasive mechanical ventilation, chronic hypercapnia, oxygen therapy at home and steroid treatment).
Ninety-nine patients with diagnosis of PVCLD with one or more years of follow-up were included in the study. The median duration of follow-up was 3.10 years. The median age at onset of the disease was 0.50 years.
According to the growth in height, there were 48 children with normal growth (Type A) and 50 with slow growth (Type B) followed by catch-up growth (N=45) or normal growth velocity (N=5); only one patient showed persistent slow growth. Chronic hypercapnia was a risk factor significantly associated to slow growth, with odds ratio, OR: 5.03; and 95% confidence interval, CI: 1.83/13.83. Patients with higher weight for height at the end of the slow-growth period showed greater gains in height during the following period (r=0.46).
Growth in children with PVCLD is heterogeneous but, in the majority of individual cases, it can be considered satisfactory. Chronic hypercapnia was associated with slow growth.
腺病毒引起的急性下呼吸道感染是婴儿慢性肺病（CLD）的重要病因。本文的目的是描述病毒性慢性肺病（PVCLD）患儿的身高和体重增长情况，并将其与相关变量（有创机械通气、慢性高碳酸血症、家庭氧疗和类固醇治疗）相关联。
本研究纳入了99例诊断为PVCLD且随访1年或以上的患者。随访的中位时长为3.10年。疾病发病时的中位年龄为0.50岁。
根据身高增长情况，有48例患儿生长正常（A型），50例生长缓慢（B型），随后出现追赶生长（N = 45）或生长速度正常（N = 5）；只有1例患者持续生长缓慢。慢性高碳酸血症是与生长缓慢显著相关的危险因素，比值比（OR）为5.03；95%置信区间（CI）为1.83/13.83。生长缓慢期结束时身高体重比更高的患者在随后时期身高增长更大（r = 0.46）。
PVCLD患儿的生长情况存在异质性，但在大多数个体病例中，可以认为是令人满意的。慢性高碳酸血症与生长缓慢有关。
