Wadell G, Cooney M K, da Costa Linhares A, de Silva L, Kennett M L, Kono R, Gui-Fang R, Lindman K, Nascimento J P, Schoub B D
J Clin Microbiol. 1985 Mar;21(3):403-8. doi: 10.1128/jcm.21.3.403-408.1985.
Adenovirus 7 (Ad7) is the adenovirus species that most frequently has been associated with severe illness. Seven distinct genome types of adenovirus 7, Ad7p, Ad7a, Ad7b, Ad7c, Ad7d, Ad7e, and Ad7f, can be identified by using restriction endonucleases BamHI and SmaI. We analyzed the distribution of the different Ad7 genome types among 314 isolates from patients and healthy shedders. The Ad7b and Ad7c genome types accounted for 90% of the isolates from patients and appeared to be mutually exclusive. A shift from Ad7c to Ad7b genome types occurred in 1969 in Europe and in 1975 in Australia. During the last decade, Ad7b genome types predominated in Australia, Europe, and North America. Ad7c was detected in South Africa, Ad7d was detected in China, Ad7e was detected in Brazil, and Ad7f was detected in Australia. The Ad7p and Ad7a genome types dominated among isolates obtained from healthy shedders and appeared scattered through the years and the geographical areas. The prevalence of Ad7 infections is high in Japan as judged by the herd immunity. However, the low percentage (2%) of Ad7 isolates among all adenovirus isolates chiefly from patients, coupled with 30 to 50% antibody prevalence, argues for a high proportion of inapparent infections and, hence, Ad7 strain(s) of low pathogenicity.
腺病毒7型（Ad7）是最常与严重疾病相关的腺病毒种类。通过使用限制性内切酶BamHI和SmaI，可以鉴定出腺病毒7型的七种不同基因组类型，即Ad7p、Ad7a、Ad7b、Ad7c、Ad7d、Ad7e和Ad7f。我们分析了314株来自患者和健康排毒者的分离株中不同Ad7基因组类型的分布情况。Ad7b和Ad7c基因组类型占患者分离株的90%，且似乎相互排斥。1969年在欧洲以及1975年在澳大利亚发生了从Ad7c基因组类型到Ad7b基因组类型的转变。在过去十年中，Ad7b基因组类型在澳大利亚、欧洲和北美占主导地位。在南非检测到Ad7c，在中国检测到Ad7d，在巴西检测到Ad7e，在澳大利亚检测到Ad7f。Ad7p和Ad7a基因组类型在从健康排毒者获得的分离株中占主导地位，并且在多年间和不同地理区域中分布较为分散。根据群体免疫判断，Ad7感染在日本的患病率很高。然而，在主要来自患者的所有腺病毒分离株中，Ad7分离株的比例较低（2%），再加上30%至50%的抗体流行率，这表明存在高比例的隐性感染，因此Ad7毒株的致病性较低。
