De Letter Miet, Santens Patrick, De Bodt Marc, Boon Paul, Van Borsel John
Department of Oto-Rhino-Laryngology, Center for Speech and Hearing Disorders, Gent University Hospital, Belgium.
Acta Neurol Belg. 2006 Mar;106(1):19-22.
The effect of speech rate on overall intelligibility in Parkinson's Disease (PD) is still a matter of debate. A comparison of the results of previous studies on speech rate in PD is hampered by methodological differences. In this study, we evaluated the effects of levodopa on speech rate and on its variability in a standardized reading task. Twenty-five patients were studied before and after levodopa administration while reading a standardized text. In accordance with previous studies, no significant improvement of speech rate was found. Rather an increased variability of speech rate in the on-medication state could be demonstrated. It is possible that this increased variability may be the consequence of respiratory deficits due to levodopa-induced dyskinesia or an increase of dysfluencies. However, the effects of defective auditory feedback and disturbed executive function cannot be ruled out.
语速对帕金森病（PD）整体可懂度的影响仍存在争议。先前关于PD语速的研究结果比较因方法学差异而受阻。在本研究中，我们在一项标准化阅读任务中评估了左旋多巴对语速及其变异性的影响。25名患者在服用左旋多巴前后阅读标准化文本时接受了研究。与先前的研究一致，未发现语速有显著改善。相反，在服药状态下可证明语速变异性增加。这种变异性增加可能是左旋多巴诱发的运动障碍导致呼吸功能缺陷或言语不流畅增加的结果。然而，听觉反馈缺陷和执行功能障碍的影响也不能排除。
