官能化5-氧代-4,5-二氢茚并[1,2-b]吡喃的三组分合成
Three-component synthesis of functionalized 5-oxo-4,5-dihydroindeno[1,2-b]pyrans.
作者信息
Yavari Issa, Sirouspour Mehdi, Souri Sanaz
机构信息
Chemistry Department, Tarbiat Modarres University, PO Box 14115-175, Tehran, Iran.
出版信息
Mol Divers. 2006 May;10(2):265-70. doi: 10.1007/s11030-006-9022-8. Epub 2006 Jun 16.
PMID:16779612
Abstract
Protonation of the reactive intermediates produced in the reaction between alkyl(aryl) isocyanides and dialkyl acetylenedicarboxylates by indan-1,3-dione leads to vinylnitrilium cations, which undergo carbon centered Michael type addition with the conjugate base of the CH-acid to produce functionalized 5-oxo-4,5-dihydroindeno[1,2-b]pyrans.
摘要
茚满-1,3-二酮使烷基（芳基）异腈与二烷基乙炔二羧酸酯反应生成的反应中间体质子化，生成乙烯基腈鎓阳离子，该阳离子与碳氢酸的共轭碱发生以碳为中心的迈克尔型加成反应，生成官能化的5-氧代-4,5-二氢茚并[1,2-b]吡喃。
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