异氰化物、二烷基丙炔二羧酸酯和反式肉桂酰氯的三组分反应合成高官能化 2-乙烯基呋喃。
Three-component reactions of isocyanides, dialkyl acetylenedicarboxylates, and trans-cinnamoyl chlorides for the synthesis of highly functionalized 2-vinyl furans.
机构信息
Chemistry Department, University of Birjand, Birjand, Iran.
出版信息
Mol Divers. 2012 Feb;16(1):145-50. doi: 10.1007/s11030-011-9341-2. Epub 2011 Dec 16.
PMID:22173695
Abstract
In this study, we present a convenient and efficient method for the synthesis of novel, highly substituted 2-vinyl furans using a three-component reaction. The zwitterions generated from the reaction of isocyanides and dialkyl acetylenedicarboxylates are reacted with trans-cinnamoyl chlorides to produce the desired products in good yields.
摘要
在这项研究中，我们提出了一种方便、高效的方法，用于通过三组分反应合成新型的高取代 2-乙烯基呋喃。异氰化物和二烷基丙二酸盐反应生成的两性离子与反式肉桂酰氯反应，以良好的产率得到所需产物。
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