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2-(烷基亚氨基亚甲基)-3-(2,2,5-三甲基-4,6-二氧代-1,3-二氧杂环己烷-5-基)琥珀酸二烷基酯的三组分合成

Three-component synthesis of dialkyl 2-(alkylimino-methylene)3- (2,2,5-trimethyl-4,6-dioxo-1,3-dioxan-5-yl)-succinates.

作者信息

Yavari Issa, Zare Hasan, Mohtat Bita

机构信息

Department of Chemistry, Science & Research Campus, Islamic Azad University, Ponak, Tehran, Iran.

出版信息

Mol Divers. 2006 May;10(2):247-50. doi: 10.1007/s11030-005-9010-4. Epub 2006 Jun 13.

DOI:10.1007/s11030-005-9010-4
PMID:16770515
Abstract

The adduct produced in the reaction between alkyl isocyanides and dialkyl acetylenedicarboxylates was trapped by 2,2,5-trimethyl-1,3-dioxane-4,6-dione (methyl Meldrum's acid), to afford highly functionalized ketenimines in good yields.

摘要

烷基异腈与二烷基乙炔二羧酸酯反应生成的加合物被2,2,5-三甲基-1,3-二恶烷-4,6-二酮（甲基丙二酸亚异丙酯）捕获，以良好的产率得到高度官能化的烯酮亚胺。

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本文引用的文献

1
Strategies for heterocyclic construction via novel multicomponent reactions based on isocyanides and nucleophilic carbenes.基于异腈和亲核卡宾通过新型多组分反应构建杂环的策略。
Acc Chem Res. 2003 Dec;36(12):899-907. doi: 10.1021/ar020258p.
2
Multicomponent Reactions with Isocyanides.异腈参与的多组分反应
Angew Chem Int Ed Engl. 2000 Sep 15;39(18):3168-3210. doi: 10.1002/1521-3773(20000915)39:18<3168::aid-anie3168>3.0.co;2-u.