Bhatia Triptish, Thomas Pramod, Semwal Prachi, Thelma B K, Nimgaonkar V L, Deshpande Smita N
Indo-US Projects on Schizophrenia Genetics, Department of Psychiatry, Dr Ram Manohar Lohia Hospital, New Delhi, India.
Schizophr Res. 2006 Sep;86(1-3):208-14. doi: 10.1016/j.schres.2006.04.015. Epub 2006 Jun 15.
Suicide is one of the most common causes of death among persons with schizophrenia. Differing risk factors have been identified in published studies. The differences may have arisen because a uniform set of variables was not analyzed. Alternatively, the nature and effect of risk factors may vary in different settings. To test these possibilities, we investigated the same set of variables in two independent cross-national samples ascertained using identical protocols.
Patients with schizophrenia or schizoaffective disorder (DSM IV criteria) were recruited in India (n=460) and the USA (n=424).
Consistent with earlier publications, a diagnosis of schizoaffective disorder, history of depression, pattern of symptoms and educational status were significantly associated with suicide attempts in the US sample. None of these variables were significantly associated in the Indian sample.
The impact of known risk factors for suicide attempts among patients with schizophrenia differs across ethnic groups.
自杀是精神分裂症患者中最常见的死亡原因之一。已发表的研究中确定了不同的风险因素。这些差异可能是因为没有分析一组统一的变量。或者，风险因素的性质和影响在不同环境中可能有所不同。为了检验这些可能性，我们在两个使用相同方案确定的独立跨国样本中调查了同一组变量。
在印度（n = 460）和美国（n = 424）招募了符合精神分裂症或分裂情感性障碍（DSM-IV标准）的患者。
与早期出版物一致，在美国样本中，分裂情感性障碍的诊断、抑郁病史、症状模式和教育状况与自杀未遂显著相关。在印度样本中，这些变量均无显著相关性。
精神分裂症患者自杀未遂的已知风险因素的影响在不同种族群体中有所不同。
