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中国精神分裂症患者自杀相关行为的综合荟萃分析。

Suicide-related behaviours in schizophrenia in China: a comprehensive meta-analysis.

机构信息

Faculty of Health Sciences,University of Macau,Macao SAR,China.

Guangdong Mental Health Center, Guangdong General Hospital & Guangdong Academy of Medical Sciences,Guangdong Province,China.

出版信息

Epidemiol Psychiatr Sci. 2019 Jun;28(3):290-299. doi: 10.1017/S2045796017000476. Epub 2017 Sep 25.

Abstract

AIMS

Suicide-related behaviours are common in schizophrenia and are significantly associated with premature death. The objective of this meta-analysis study was to estimate the pooled prevalence of suicide-related behaviours in schizophrenia patients in China.

METHODS

The relevant literature was searched systematically via the relevant electronic databases (PubMed, Embase, PsycINFO, Chinese National Knowledge Infrastructure, Wanfang Databases and Chinese Biological Medical Literature Database) from their inception until 14 September 2016. Only original studies that reported the prevalence of suicide-related behaviours including suicidal ideation (SI), suicide plan, suicide attempt (SA) and completed suicide were selected.

RESULTS

Nineteen articles met the inclusion criteria and were analysed. The pooled lifetime prevalence of SI and SA were 25.8% (95% CI 14.7-41.1%) and 14.6% (95% CI 9.1-22.8%), respectively. The 1-month prevalence of SI was 22.0% (95% CI 18.2-26.4%). Subgroup analyses of lifetime SI and SA showed that gender, sample size, survey year, study location and source of patients have no significant mediating effects on the results.

CONCLUSIONS

Suicide-related behaviours are common in Chinese schizophrenia patients. Due to the high mortality risk, regular screening and effective suicide prevention programmes are warranted.

摘要

目的

自杀相关行为在精神分裂症中很常见,与过早死亡显著相关。本荟萃分析旨在评估中国精神分裂症患者自杀相关行为的总体发生率。

方法

通过相关电子数据库(PubMed、Embase、PsycINFO、中国国家知识基础设施、万方数据库和中国生物医学文献数据库)系统地检索相关文献,检索时间截至 2016 年 9 月 14 日。仅纳入报告自杀相关行为(包括自杀意念、自杀计划、自杀未遂和自杀完成)发生率的原始研究。

结果

符合纳入标准的文献共 19 篇,进行荟萃分析。精神分裂症患者终生自杀意念和自杀未遂的发生率分别为 25.8%(95%CI 14.7-41.1%)和 14.6%(95%CI 9.1-22.8%)。1 个月时自杀意念的发生率为 22.0%(95%CI 18.2-26.4%)。亚组分析显示,性别、样本量、调查年份、研究地点和患者来源对终生自杀意念和自杀未遂的发生率无显著影响。

结论

自杀相关行为在我国精神分裂症患者中很常见。由于其高死亡率,需要定期进行筛查,并实施有效的自杀预防计划。

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