Irvine C, Irvine F, Champion R H
Kent and Canterbury Hospital, England.
Acta Derm Venereol. 1991;71(3):242-4.
Several large series of patients with lichen planus were reported some 30 years ago but no recent large surveys have been published. In this study, detailed enquiry was made into the natural history of the disease in 214 patients followed up 8 to 12 years after presentation to the Dermatology Department. The key findings from this study showed that the mean age of onset of lichen planus in males was significantly lower than in females (40.3 years in males compared with 46.4 years in females, p less than 0.05). The main eruption of lichen planus cleared within one year in 68% of the patients but we found a higher recurrence rate than in previous series at 49%. Many patients suffered from persistent brown staining many years after the rash had cleared.
大约30年前曾有几篇关于扁平苔藓患者的大型系列报道，但近期尚未发表大型调查研究。在本研究中，我们对214例患者进行了详细调查，这些患者在就诊于皮肤科后接受了8至12年的随访，以了解该疾病的自然病程。该研究的主要发现表明，男性扁平苔藓的平均发病年龄显著低于女性（男性为40.3岁，女性为46.4岁，p<0.05）。68%的患者扁平苔藓的主要皮疹在1年内消退，但我们发现复发率高于之前系列报道，为49%。许多患者在皮疹消退多年后仍有持续性褐色色素沉着。
