Millanta F, Calandrella M, Vannozzi I, Poli A
Department of Animal Pathology, University of Pisa, Viale delle Piagge 2, I-56124 Pisa, Italy.
Vet Rec. 2006 Jun 17;158(24):821-4. doi: 10.1136/vr.158.24.821.
The expression of oestrogen-alpha and progesterone receptors was determined in 13 normal, 21 dysplastic and 53 neoplastic feline mammary tissues. Expression of the receptors was correlated with cell proliferation, as assessed by the MIB-1 immunolabelling index, and with the clinical course of the disease. The expression of oestrogen receptors was significantly higher in healthy tissues and in adenosis than in neoplastic lesions, and the levels of progesterone receptors increased in fibroadenomatous changes and in "in situ" carcinomas but decreased in invasive carcinomas. The oestrogen and progesterone receptor status of the invasive carcinomas did not correlate either with the histological parameters or with the overall survival of the cats, although the oestrogen receptor-negative tumours had a poor prognosis. Oestrogen receptor-positive neoplasms had a significantly lower MIB-1 immunolabelling index than oestrogen receptor-negative neoplasms.
在13个正常、21个发育异常和53个肿瘤性猫乳腺组织中测定了雌激素α和孕激素受体的表达。通过MIB-1免疫标记指数评估，受体的表达与细胞增殖相关，并与疾病的临床进程相关。雌激素受体在健康组织和腺病中的表达显著高于肿瘤性病变，孕激素受体水平在纤维腺瘤样改变和“原位”癌中升高，但在浸润性癌中降低。浸润性癌的雌激素和孕激素受体状态与组织学参数或猫的总生存率均无相关性，尽管雌激素受体阴性肿瘤预后较差。雌激素受体阳性肿瘤的MIB-1免疫标记指数显著低于雌激素受体阴性肿瘤。
