Sijvarger C C, González J V, Prieto A, Messmer A G, Mallimaci M C, Alonio V L, Teyssié A R, Picconi M A
Servicio de Laboratorio, Hospital Regional Ushuaia, 12 de Octubre y Maipú, (9410) Ushuaia, Tierra del Fuego, Argentina.
Rev Argent Microbiol. 2006 Jan-Mar;38(1):19-24.
Genital infection with human papillomavirus (HPV) is decisive in the causation of cervical cancer. In order to evaluate the epidemiology of HPV infection in Ushuaia, Province of Tierra del Fuego, Argentina, 132 endocervical cytobrushes from preneoplastic and neoplastic cases and controls were studied. Detection and typing of the viral genome was performed by polymerase chain reaction, combined with a restriction fragment length polymorphism assay or hybridization. The overall prevalence of HPV infection was 41% in the population examined, with a frequency of 26% in the controls and 71% in the cases under study. The 14-24 age group showed the highest HPV prevalence. The most common viral types in the infected population were HPV 16 (23%), HPV 18 (11%), HPV 33 (8%) and HPV 35 (8%), while high risk viral types were detected in 30% of the samples, 16% of the controls and 60% of the cases. This study provides the first data on the predominant viral types in Ushuaia. Our results show lower levels of infection than in regions with a high incidence of cervical cancer, HPV 16 being the most prevalent viral type. This research may be useful for selecting a specific vaccine targeting the population examined.
人乳头瘤病毒（HPV）生殖器感染在宫颈癌病因中起决定性作用。为评估阿根廷火地岛省乌斯怀亚市HPV感染的流行病学情况，对取自癌前病变、肿瘤病变病例及对照的132支子宫颈内膜细胞刷进行了研究。通过聚合酶链反应结合限制性片段长度多态性分析或杂交进行病毒基因组的检测和分型。在所检查人群中，HPV感染的总体患病率为41%，对照组为26%，研究中的病例组为71%。14 - 24岁年龄组的HPV患病率最高。感染人群中最常见的病毒类型为HPV 16（23%）、HPV 18（11%）、HPV 33（8%）和HPV 35（8%），高危病毒类型在30%的样本、16%的对照组和60%的病例组中被检测到。本研究提供了乌斯怀亚市主要病毒类型的首批数据。我们的结果显示，与宫颈癌高发地区相比，感染水平较低，HPV 16是最普遍的病毒类型。这项研究可能有助于针对所检查人群选择特定疫苗。
