Tonon S A, Picconi M A, Zinovich J B, Nardari W, Mampaey M, Galuppo J A, Bos P D, Badano I, Di Lello F A, Basiletti J, González J V, Alonio L V, Teyssié A R
Laboratorio de Biología Molecular Aplicada, F.C.E., Q.yN., Universidad Nacional de Misiones, Félix de Azara 1552, 3300 Posadas, Misiones.
Rev Argent Microbiol. 2003 Oct-Dec;35(4):205-13.
A genital infection with human papillomavirus (HPV) of a high risk type is necessary for the development of cervical carcinoma. HPV viral distribution among diverse world populations is not homogeneous, viral reservoirs having been detected in particular regions that can interact when humans engage in active contacts. Such viral dynamics alters the population cervical cancer relative risk, particularly when the prevalence of HPV oncogenic risk types is high. We have compared women exposed to different social, cultural and environmental conditions regarding cervical HPV infection, analyzing two populations from Misiones, Argentina: White urban women and--Guarani indian women living in the rain forest. Demographic, clinical and sexual behavior data were collected and cytological, colposcopical and virological analysis performed. Detection and genotypification of HPV was performed by PCR-RFLP. The prevalence for generic HPV infection found was high in both populations, urban women: 43%, Guarani indians: 60%, with a statistically significant difference. These values were positively associated to age of first intercourse, number of male partners and smoking history. HPV type-specific prevalences showed a relative homogeneity between populations when the main representatives of the high risk (16 and 18: 23%) and low risk (6 y 11: 12%) types were grouped together. However, the presence of other viral types was notoriously different, representing only 9% in urban women and 29% in Guarani indians with particularly high risk HPV types (33, 35, 39, 45, 51, 52, 58, 67, 68). This situation might be of importance for future viral dynamics, phylogenetic and vaccine formulation studies.
高危型人乳头瘤病毒（HPV）的生殖器感染是宫颈癌发生的必要条件。HPV在世界不同人群中的分布并不均匀，在特定区域检测到病毒库，当人类进行活跃接触时这些区域可能相互作用。这种病毒动态变化改变了人群患宫颈癌的相对风险，尤其是当HPV致癌风险型的流行率较高时。我们比较了处于不同社会、文化和环境条件下的女性的宫颈HPV感染情况，分析了来自阿根廷米西奥内斯省的两个人群：城市白人女性和生活在雨林中的瓜拉尼印第安女性。收集了人口统计学、临床和性行为数据，并进行了细胞学、阴道镜检查和病毒学分析。通过PCR-RFLP进行HPV的检测和基因分型。在两个人群中，一般HPV感染的患病率都很高，城市女性为43%，瓜拉尼印第安人为60%，差异有统计学意义。这些值与首次性交年龄、男性伴侣数量和吸烟史呈正相关。当将高危型（16和18型：23%）和低危型（6和11型：12%）的主要代表类型归为一组时，HPV型特异性患病率在人群之间显示出相对一致性。然而，其他病毒类型的存在差异显著，在城市女性中仅占9%，在瓜拉尼印第安人中占29%，其中高危HPV类型（33、35、39、45、51、52、58、67、68）尤为突出。这种情况可能对未来的病毒动态变化、系统发育和疫苗配方研究具有重要意义。
