Fong Siew Wan, Klaseboer Evert, Turangan Cary K, Khoo Boo Cheong, Hung Kin Chew
Institute of High Performance Computing, Singapore.
Ultrasound Med Biol. 2006 Jun;32(6):925-42. doi: 10.1016/j.ultrasmedbio.2006.03.005.
Ultrasonic cavitation bubble phenomena play a key role in numerous medical procedures such as ultrasound-assisted lipoplasty, phacoemulsification, lithotripsy, brain tumor surgery, muscle and bone therapies and intraocular or transdermal drug delivery. This study investigates numerically the interaction of a bubble with a bio-material (fat, skin, cornea, brain, muscle, cartilage or bone) involved in the treatments mentioned when subjected to an ultrasound field. A range of frequencies is used to study the bubble behavior in terms of its growth and collapse shapes, and the maximum jet velocity attained. Simulation results show complex dynamic behaviors of the bubble. In several cases a jet is formed directed away from the bio-material while in others, toward it. In certain cases, the bubble eventually breaks into two, with or without the formation of opposite penetrating jets. Very high maximum velocities of jets directing away or toward the bio-materials can be observed in some cases (700 to 900 ms(-1)).
超声空化气泡现象在众多医疗程序中发挥着关键作用，如超声辅助脂肪抽吸术、超声乳化白内障吸除术、碎石术、脑肿瘤手术、肌肉和骨骼治疗以及眼内或经皮给药。本研究对在超声场作用下，气泡与上述治疗中涉及的生物材料（脂肪、皮肤、角膜、脑、肌肉、软骨或骨骼）之间的相互作用进行了数值研究。使用一系列频率来研究气泡在其生长和坍塌形状方面的行为，以及达到的最大射流速度。模拟结果显示了气泡复杂的动态行为。在几种情况下，会形成远离生物材料的射流，而在其他情况下，则是朝向生物材料。在某些情况下，气泡最终会分裂成两个，有无相反穿透射流的形成。在某些情况下，可以观察到远离或朝向生物材料的射流具有非常高的最大速度（700至900米/秒）。
