Redfern J S, Lin H J, McArthur K E, Prince M D, Feldman M
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
Am J Physiol. 1991 Aug;261(2 Pt 1):G295-304. doi: 10.1152/ajpgi.1991.261.2.G295.
In conscious, gastric fistula rabbits, gastric acid and pepsin secretion averaged 4.5 +/- 0.1 mmol/h (1.3 mmol.kg-1.h-1) and 4.9 +/- 0.3 IU/h (1.6 IU.kg-1.h-1), respectively; these values represent approximately 40-50% of maximal output. Basal serum gastrin concentrations averaged 24 +/- 4 pg/ml and did not correlate with basal acid secretion. Atropine and vagotomy incompletely inhibited basal acid secretion (by 84 and 50%, respectively) and completely inhibited 2-deoxy-D-glucose-stimulated gastric acid secretion. Atropine and vagotomy similarly inhibited basal pepsin secretion by 50 and 40%, respectively. Ranitidine decreased acid and pepsin secretion, but as with atropine, inhibition was not complete (73 and 37%, respectively). Although omeprazole did not affect pepsin secretion, omeprazole completely inhibited basal acid secretion and elevated postprandial intragastric pH above 5.0. Conscious, gastric fistula rabbits have the highest basal acid and pepsin output among species commonly studied. Both vagal-cholinergic pathways and histamine drive basal acid and pepsin secretion in the rabbit.
在清醒的胃瘘兔中，胃酸和胃蛋白酶分泌平均分别为4.5±0.1 mmol/h（1.3 mmol·kg⁻¹·h⁻¹）和4.9±0.3 IU/h（1.6 IU·kg⁻¹·h⁻¹）；这些值约为最大分泌量的40 - 50%。基础血清胃泌素浓度平均为24±4 pg/ml，与基础酸分泌无相关性。阿托品和迷走神经切断术不完全抑制基础酸分泌（分别为84%和50%），并完全抑制2-脱氧-D-葡萄糖刺激的胃酸分泌。阿托品和迷走神经切断术同样分别抑制基础胃蛋白酶分泌50%和40%。雷尼替丁减少酸和胃蛋白酶分泌，但与阿托品一样，抑制不完全（分别为73%和37%）。尽管奥美拉唑不影响胃蛋白酶分泌，但它完全抑制基础酸分泌，并使餐后胃内pH值升高至5.0以上。清醒的胃瘘兔在常见研究的物种中基础酸和胃蛋白酶分泌量最高。迷走胆碱能途径和组胺均驱动兔的基础酸和胃蛋白酶分泌。
