Couturier Jennifer, Lock James
Department of Psychiatry, University of Western Ontario, London, Ontario, Canada.
Int J Eat Disord. 2006 Nov;39(7):550-5. doi: 10.1002/eat.20309.
The principal aim of this study is to describe the types of problems faced in defining recovery from anorexia nervosa (AN) as well as to illustrate the magnitude that various definitions have on recovery rates for AN.
Comparative rates of recovery from AN using a range of definitions (percent ideal body weight, psychological recovery, and combinations of these variables) were calculated using long-term outcome data from a study of adolescents treated for AN. In addition, a Kaplan-Meier survival analysis was used to model recovery over the long-term follow-up period.
Recovery rates varied highly, depending on the definition used, from 57.1% to 94.4%. Using survival analysis, the mean time to remission for weight (>85% ideal body weight) was 11.3 months, significantly shorter than for Eating Disorder Examination score recovery at 22.6 months (log rank = 16.1, p = 0.0001).
Agreement of definitions of recovery may be dependent on specific goals of a particular study or treatment; however, in order to compare and contrast categorical outcomes, a consistent definition of recovery is needed in the literature. Both weight and psychological symptoms appear to be important in a definition of recovery.
本研究的主要目的是描述在定义神经性厌食症(AN)康复时所面临的问题类型,并说明各种定义对AN康复率的影响程度。
利用一项针对接受AN治疗的青少年的研究中的长期结果数据,计算使用一系列定义(理想体重百分比、心理康复以及这些变量的组合)时AN的康复比较率。此外,使用Kaplan-Meier生存分析对长期随访期内的康复情况进行建模。
康复率差异很大,取决于所使用的定义,从57.1%到94.4%不等。使用生存分析,体重恢复至(>理想体重的85%)的平均缓解时间为11.3个月,明显短于饮食失调检查得分恢复的平均时间22.6个月(对数秩=16.1,p=0.0001)。
康复定义的一致性可能取决于特定研究或治疗的具体目标;然而,为了比较和对比分类结果,文献中需要一个一致的康复定义。体重和心理症状在康复定义中似乎都很重要。