Suppr超能文献

饮食失调患者的缓解时间:一项为期2.5年的结局及预测因素随访研究。

Time to remission for eating disorder patients: a 2(1/2)-year follow-up study of outcome and predictors.

作者信息

Clausen Loa

机构信息

Eating Disorder Centre, Harald Selmersvej 66, 8240 Risskov, Denmark.

出版信息

Nord J Psychiatry. 2008;62(2):151-9. doi: 10.1080/08039480801984875.

Abstract

The aim of the present study was to analyse outcome, time to remission, and predictors of time to remission in a cohort of Danish eating disorder patients. Seventy-eight patients (35 anorexic, 30 bulimic and 13 unspecified eating disorder patients) were interviewed 2(1/2) years after initial assessment. Method of assessment was Eating Disorder Examination (EDE), Longitudinal Interval Follow-up Evaluation of Eating Disorders (LIFE-EAT-II), Eating Disorder Inventory (EDI), Symptom Check List (SCL-90R), Present State Examination (PSE) and the Structured Clinical Interview for DSM-III-R Axis-II (SCID-II). Method of analysis was Kaplan-Meier estimate of survival, Log Rank test and Cox regression analysis. In total 48.7% reached remission with mean time to remission at 27 months. A trend difference between the diagnostic groups when measuring time to remission was found, i.e. patients with unspecified eating disorders remitted faster than bulimic (BN) patients who in turn remitted faster than anorexic (AN) patients. Body mass index (BMI) at baseline was the best predictor of time to remission for the total sample. Predictors differed when looking at diagnostic groups separately. Final outcome was comparable with earlier studies while relapse frequency was low. Patients with AN remitted faster than found in earlier survival analysis studies, while the remission rate for BN patients was comparable with earlier studies. Despite the prognostic value of BMI for the total sample, predictor analysis implied more disorder diversity than homogeneity.

摘要

本研究的目的是分析一组丹麦饮食失调患者的治疗结果、缓解时间以及缓解时间的预测因素。在初次评估2.5年后,对78名患者(35名神经性厌食症患者、30名神经性贪食症患者和13名未明确诊断的饮食失调患者)进行了访谈。评估方法包括饮食失调检查(EDE)、饮食失调纵向间隔随访评估(LIFE-EAT-II)、饮食失调量表(EDI)、症状自评量表(SCL-90R)、现状检查(PSE)以及DSM-III-R轴II型结构化临床访谈(SCID-II)。分析方法包括Kaplan-Meier生存估计、对数秩检验和Cox回归分析。总体而言,48.7%的患者达到缓解,平均缓解时间为27个月。在测量缓解时间时,发现诊断组之间存在趋势差异,即未明确诊断的饮食失调患者比神经性贪食症(BN)患者缓解得更快,而神经性贪食症患者又比神经性厌食症(AN)患者缓解得更快。基线时的体重指数(BMI)是总样本缓解时间的最佳预测因素。单独观察诊断组时,预测因素有所不同。最终结果与早期研究相当,而复发频率较低。神经性厌食症患者的缓解速度比早期生存分析研究中发现的要快,而神经性贪食症患者的缓解率与早期研究相当。尽管BMI对总样本具有预后价值,但预测因素分析表明,疾病的多样性多于同质性。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验