Crasta Karen, Surana Uttam
Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, 138673, Singapore.
Cell Div. 2006 Jun 22;1:12. doi: 10.1186/1747-1028-1-12.
Accurate transmission of chromosomes from parent to progeny cell requires assembly of a bipolar spindle. Centrosomes (spindle pole body in yeast) are critical for the biogenesis of this complex mitotic apparatus since they confer bipolarity on the spindle and serve as the site of microtubule polymerization. In each division cycle, the centrosome is duplicated and the sister-centrosomes move away from each other, forming the two poles of the spindle. While the structure and the duplication of centrosomes have been investigated extensively, the understanding of the control of their segregation remains scant. Recent findings are beginning to yield insights into the regulation of centrosome segregation in yeast and its link to the mitotic kinase.
染色体从亲代细胞准确传递到子代细胞需要双极纺锤体的组装。中心体（酵母中的纺锤极体）对于这种复杂的有丝分裂装置的生物发生至关重要，因为它们赋予纺锤体双极性，并作为微管聚合的位点。在每个分裂周期中，中心体被复制，姐妹中心体相互远离，形成纺锤体的两极。虽然对中心体的结构和复制进行了广泛研究，但对其分离控制的理解仍然不足。最近的研究结果开始揭示酵母中中心体分离的调控及其与有丝分裂激酶的联系。
