Hanganu Ileana L, Ben-Ari Yehezkel, Khazipov Rustem
Institut de Neurobiologie de la Mediteranée, Université de la Mediteranée, Institut National de la Santé et de la Recherche Médicale U29, 13273 Marseille, France.
J Neurosci. 2006 Jun 21;26(25):6728-36. doi: 10.1523/JNEUROSCI.0752-06.2006.
During visual system development, the light-insensitive retina spontaneously generates waves of activity, which are transmitted to the lateral geniculate nucleus. The crucial question is whether retinal waves are further transmitted to the cortex and influence the early cortical patterns of activity. Using simultaneous recordings from the rat retina and visual cortex during the first postnatal week in vivo, we found that spontaneous retinal bursts are correlated with spindle bursts (intermittent network bursts associated with spindle-shape field oscillations) in the contralateral visual cortex (V1). V1 spindle bursts could be evoked by electrical stimulation of the optic nerve. Intraocular injection of forskolin, which augments retinal waves, increased the occurrence of V1 spindle bursts. Blocking propagation of retinal activity, or removal of the retina reduced the frequency, but did not completely eliminate the cortical spindle bursts. These results indicate that spontaneous retinal waves are transmitted to the visual cortex and trigger endogenous spindle bursts. We propose that the interaction between retinal waves and spindle bursts contributes to the development of visual pathways to the cortex.
在视觉系统发育过程中，对光不敏感的视网膜会自发产生活动波，这些活动波会传递到外侧膝状体核。关键问题在于视网膜波是否会进一步传递到皮层并影响早期皮层活动模式。在出生后第一周对大鼠视网膜和视觉皮层进行体内同步记录，我们发现自发的视网膜爆发与对侧视觉皮层（V1）中的纺锤体爆发（与纺锤形场振荡相关的间歇性网络爆发）相关。V1纺锤体爆发可通过对视神经的电刺激诱发。眼内注射可增强视网膜波的福斯高林会增加V1纺锤体爆发的发生率。阻断视网膜活动的传播或摘除视网膜会降低频率，但并未完全消除皮层纺锤体爆发。这些结果表明，自发的视网膜波会传递到视觉皮层并触发内源性纺锤体爆发。我们认为视网膜波与纺锤体爆发之间的相互作用有助于视觉通路向皮层的发育。
