Linden Monica L, Heynen Arnold J, Haslinger Robert H, Bear Mark F
Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Cambridge, Massachusetts, USA.
Nat Neurosci. 2009 Apr;12(4):390-2. doi: 10.1038/nn.2284. Epub 2009 Mar 1.
Manipulations of activity in one retina can profoundly affect binocular connections in the visual cortex. Retinal activity is relayed to the cortex by the dorsal lateral geniculate nucleus (dLGN). We compared the qualities and amount of activity in the dLGN following monocular eyelid closure and monocular retinal inactivation in awake mice. Our findings substantially alter the interpretation of previous studies and define the afferent activity patterns that trigger cortical plasticity.
对一侧视网膜活动的操控可深刻影响视觉皮层中的双眼连接。视网膜活动通过背侧外侧膝状体核（dLGN）传递至皮层。我们比较了清醒小鼠单眼眼睑闭合和单眼视网膜失活后dLGN中活动的性质和量。我们的发现极大地改变了对先前研究的解读，并确定了触发皮层可塑性的传入活动模式。
