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嗜睡的主观和客观测量:苯二氮䓬类药物和咖啡因对它们之间关系的影响。

Subjective and objective measures of sleepiness: effect of benzodiazepine and caffeine on their relationship.

作者信息

Johnson L C, Freeman C R, Spinweber C L, Gomez S A

机构信息

Naval Health Research Center, San Diego, CA 92186-5122.

出版信息

Psychophysiology. 1991 Jan;28(1):65-71. doi: 10.1111/j.1469-8986.1991.tb03388.x.

DOI:10.1111/j.1469-8986.1991.tb03388.x
PMID:1679563
Abstract

As part of a larger project on the effects of benzodiazepine and caffeine on daytime sleepiness, performance and mood, this study examined the relationship among the Multiple Sleep Latency Test, lapses during a tapping task, a Visual Analog Scale, and the Stanford Sleepiness scale. Subjects were 80 male, adult nonsmokers aged 20.3 +/- 2.7 years. The Multiple Sleep Latency Test, Stanford Sleepiness Scale, and the Visual Analog Scale were obtained at two-hour intervals beginning at 0700 h and ending at 1700 h. The tapping task (lapses) was administered each day at 0600 h, 1000 h, and 1400 h. A lapse was a 3-s or greater pause between taps. Correlations between the Multiple Sleep Latency Test and subjective (Visual Analog Scale and the Stanford Sleepiness Scale) measures were significant at 0600 h, but became nonsignificant as the day progressed. Correlations between lapses and the two subjective measures were generally nonsignificant. The two objective measures were significantly correlated in the total group but not in all treatment groups. The subjective measures were significantly correlated in the total sample and in each treatment group. This study reaffirms the importance of time of day when measuring sleepiness, and suggests that subjective and objective measures may measure different aspects of sleepiness.

摘要

作为一项关于苯二氮䓬类药物和咖啡因对日间嗜睡、工作表现及情绪影响的更大规模项目的一部分,本研究考察了多次睡眠潜伏期试验、敲击任务中的失误次数、视觉模拟量表和斯坦福嗜睡量表之间的关系。研究对象为80名20.3±2.7岁的成年男性非吸烟者。从07:00开始,每隔两小时进行一次多次睡眠潜伏期试验、斯坦福嗜睡量表和视觉模拟量表的测量,直至17:00结束。敲击任务(失误次数)在每天的06:00、10:00和14:00进行。失误是指两次敲击之间间隔3秒或更长时间。多次睡眠潜伏期试验与主观测量(视觉模拟量表和斯坦福嗜睡量表)之间的相关性在06:00时显著,但随着时间推移变得不显著。失误次数与两项主观测量之间的相关性通常不显著。两项客观测量在总样本组中显著相关,但在所有治疗组中并非如此。主观测量在总样本和每个治疗组中均显著相关。本研究再次证实了测量嗜睡时时间因素的重要性,并表明主观和客观测量可能衡量的是嗜睡的不同方面。

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